Optimal Skin Regeneration After Full Thickness Thermal Burn Injury in the Spiny Mouse, Acomys Cahirinus

June 2018 in “ Burns ”

Malcolm Maden

skin regeneration thermal burn injury hair follicles sebaceous glands re-epithelialization macrophage profiles cytokine responses

TLDR The spiny mouse can fully regenerate skin after burns, unlike the lab mouse.

The study demonstrated that the spiny mouse, Acomys cahirinus, exhibited remarkable regenerative abilities after full thickness thermal burn injuries, unlike the lab mouse, Mus musculus, which developed thick, hairless scars. In Acomys, the skin regenerated completely, including skeletal muscle, dermis, hair follicles, and sebaceous glands, making the skin appear indistinguishable from its original state. This regeneration was attributed to faster re-epithelialization and differences in macrophage profiles, which likely influenced cytokine responses. The study involved groups of 3 spiny mice and compared their healing process to that of the lab mice, highlighting the potential for understanding skin regeneration mechanisms.

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Research cited in this study

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research Skin Shedding and Tissue Regeneration in African Spiny Mice (Acomys)

418 citations, September 2012 in “Nature”

African spiny mice can regenerate skin, hair, and cartilage, but not muscle, and their unique abilities could be useful for regenerative medicine.

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