Tissue Engineering in Burn Scar Reconstruction

    January 2015 in “ Burns & Trauma ”
    Paul P. M. van Zuijlen, K. L. M. Gardien, M.E.H. Jaspers, EJ Bos, Dominique C. Baas, AJM van Trier, Esther Middelkoop
    TLDR Tissue engineering improves burn scar reconstruction by using skin substitutes and replacing damaged tissues.
    The article reviewed the application of tissue engineering in burn scar reconstruction, highlighting advancements in techniques and materials to improve healing and aesthetic outcomes. It discussed the evolution from early skin grafting to modern tissue-engineered products like Integra and MatriDerm, which showed promise in reducing scarring and donor site needs. Integra had a mean take rate of 76.2% but sometimes showed re-contraction in scar releases. MatriDerm improved scar elasticity and texture, with enhanced effectiveness when combined with topical negative pressure. The document also explored the potential of cell-based constructs and stem cells, emphasizing the need for further research. Additionally, it discussed challenges in reconstructing facial features, noting the potential of 3D bioprinting for customized cartilage constructs, despite high costs and regulatory hurdles. Overall, the article emphasized the importance of continued research to enhance the effectiveness and accessibility of these advanced therapeutic options for burn patients.
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