Dermal Microvascular Responses of Human Induced Pluripotent Stem Cell-Derived Skin Organoids to Inflammation and Injury
February 2026
in “
American Journal Of Pathology
”
human induced pluripotent stem cells skin organoids inflammation injury dermal microvessels re-epithelialization fibroblastic response angiogenic response epithelial cell area vascular endothelial growth factor VEGF angiogenic sprouting vasculogenesis microanatomy cellular composition skin diseases therapeutic interventions
TLDR Skin organoids can mimic human skin responses to injury and inflammation, making them useful for studying skin diseases and testing treatments.
The study examines the responses of human induced pluripotent stem cell-derived skin organoids (SKOs) to inflammation and injury, focusing on their ability to mimic native human dermal microvessels. SKOs develop extensive microvascular networks and demonstrate significant post-injury re-epithelialization, fibroblastic, and angiogenic responses, with notable increases in epithelial cell area post-injury. The presence of vascular endothelial growth factor (VEGF) enhances angiogenic sprouting. Despite some variability in vasculogenesis, SKOs closely resemble human skin in microanatomy and cellular composition, suggesting their potential as a model for studying skin diseases and testing therapeutic interventions. The study involved 438 organoids and highlights the limitations of current preclinical models, proposing SKOs as a valuable tool for future research.
