Skin Wound Healing in Humans and Mice: Challenges in Translational Research

    December 2017 in “ Journal of Dermatological Science ”
    Helena Debiazi Zomer, Andréa Gonçalves Trentin
    Studysummary This review discusses the limitations of animal models, particularly mice, in accurately predicting human skin wound healing outcomes and emphasizes understanding species-specific differences in skin characteristics for better translation to clinical settings.
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    Research cited in this study 11

    1. Defining Stem Cell Dynamics and Migration During Wound Healing in Mouse Skin Epidermis Nature Communications · 2017
    2. Two-Photon Microscopy for Intracutaneous Imaging of Stem Cell Activity in Mice Experimental Dermatology · 2016
    3. Mechanisms Regulating Skin Immunity and Inflammation Nature Reviews Immunology · 2014
    4. Regenerating the Skin: A Task for the Heterogeneous Stem Cell Pool and Surrounding Niche Nature Reviews Molecular Cell Biology · 2013
    5. Human Wharton's Jelly Stem Cells and Their Conditioned Medium Enhance Healing of Excisional and Diabetic Wounds Journal of Cellular Biochemistry · 2013
    6. Fgf9 From Dermal γδ T Cells Induces Hair Follicle Neogenesis After Wounding Nature Medicine · 2013
    7. Live Imaging of Stem Cell and Progeny Behavior in Physiological Hair-Follicle Regeneration Nature · 2012
    8. Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation Cell stem cell · 2012
    9. Comparisons of Mouse Models for Hair Follicle Reconstitution Experimental Dermatology · 2011
    10. Exploring the Role of Stem Cells in Cutaneous Wound Healing Experimental Dermatology · 2009
    11. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007