Dissecting the Microenvironment Around Biosynthetic Scaffolds in Murine Skin Wound Healing

    August 2020 in “ bioRxiv (Cold Spring Harbor Laboratory) ”
    Changwei Hu, Chenyu Chu, Li Liu, Shue Jin, Renli Yang, Shengan Rung, Jidong Li, Yang Qu, Yi Man
    Image of study
    TLDR The Aligned membranes improved wound healing and hair growth with a better immune response in mice.
    In 2020, a study was conducted on the impact of biomaterials with different surface topographies on wound healing and immune response. Three types of electrospun membranes were fabricated: Random, Aligned, and Latticed. The Aligned membranes demonstrated an immunomodulatory ability, leading to faster wound healing, reduced fibrotic response, and enhanced regeneration of cutaneous appendages in skin wound repair. Single-cell RNA sequencing analysis was performed on cells from wounded mouse skin with or without the Aligned scaffold. The Aligned group showed more hair follicle progenitor cells, inner root sheath cells (anagen-related), and fibroblast subsets, which corresponded to improved hair follicle regeneration and faster wound closure. The immune response towards the biomaterial differed from the control group, with reduced macrophages and neutrophils but more effector T cells in the Aligned samples. The scaffold possibly advanced the immune response towards an adaptive immunity-dominant stage. The microenvironment around the scaffold involved a complex interplay of immune cells and cutaneous cells, with wound healing being the result of numerous influencing factors working together.
    Discuss this study in the Community →

    Research cited in this study

    2 / 2 results

    Related Community Posts Join

    6 / 1000+ results

      community Comprehensive Microneedling Guide

      in Microneedling  293 upvotes 2 years ago
      Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.

      community 4.5 months of microneedling – progress

      in Microneedling  300 upvotes 4 years ago
      A user who has had positive results from using a regimen of microneedling, finasteride, minoxidil, peppermint oil, keto shampoo and DHT organic shampoo for hair growth. The conversation also addressed whether to use .5mg or 1mg of finasteride and the difference between dermapens and rollers.

      community Verteporfin and Microneedling

      in Treatments 6 months ago
      Clinical studies by Dr. Barghouthi and Dr. Bloxham indicate that Verteporfin, when used with FUE and FUT hair transplantation methods, shows promise in hair follicle regeneration and minimal scarring due to its ability to inhibit Yes-associated protein (YAP). Microneedling at depths of 3-3.5mm, combined with Verteporfin, could potentially reactivate dormant follicles, although the optimal dosage and application method are still under investigation. Concerns remain about the DHT sensitivity of regenerated follicles, highlighting the need for further research to optimize trauma levels and Verteporfin concentrations to achieve effective and scar-free hair regeneration.

      community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

      in Research/Science  742 upvotes 2 years ago
      A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

    Related Research

    2 / 2 results