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GlossaryKLF4

transcription factor regulating cell growth and differentiation

KLF4, or Kruppel-like factor 4, is a protein that plays a crucial role in regulating cell growth, differentiation, and maintaining stem cell pluripotency. It is involved in various biological processes, including skin and hair follicle development, and has been studied for its potential implications in cancer and regenerative medicine.

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research The Tissue-dependent Keratin 19 Gene Transcription Is Regulated by GKLF/KLF4 and Sp1

119 citations , September 2000 in “Journal of Biological Chemistry”

GKLF/KLF4 and Sp1 control Keratin 19 gene activity, influencing cancer-related changes.

research WNT10A mutation causes ectodermal dysplasia by impairing progenitor cell proliferation and KLF4-mediated differentiation

96 citations , June 2017 in “Nature Communications”

A WNT10A gene mutation leads to ectodermal dysplasia by disrupting cell growth and differentiation.

research Expression of Kruppel-Like Factor KLF4 in Mouse Hair Follicle Stem Cells Contributes to Cutaneous Wound Healing

23 citations , June 2012 in “PLOS ONE”

KLF4 is important for maintaining skin stem cells and helps heal wounds.

research Function of KLF4 in Stem Cell Biology

5 citations , August 2013 in “InTech eBooks”

KLF4 is important for maintaining stem cells and has potential in cancer treatment and wound healing.

research 1438 KLF4 maintains hair follicle stem cell quiescence

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

KLF4 is important for keeping hair follicle stem cells inactive.

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community RU55481

4 upvotes 12 years ago

community Kintors interim report from 9-2-24 for everyone whos interested

in Product 32 upvotes 1 year ago

Kintor plans to release pyrilutamide foam and a plant-based Koshine by year-end, with GT20029 progressing in their pipeline. Users are pleased about the absence of propylene glycol (PG) in the new products.

community Phase 3 of pyrilutamide (kx-836) analysis of the efficacy

in Research/Science 11 upvotes 2 years ago

The conversation discusses the less impressive results of Pyrilutamide (kx-836) in phase 3 compared to phase 2, with a suggestion that a longer study might show more significant results. One user reports personal success with Pyrilutamide, experiencing no further hair loss and gradual regrowth.

community Kintor has released an investor relations memo regarding Chinese Phase III trials for Pyrilutamide

in Update 51 upvotes 2 years ago

Kintor's Pyrilutamide (KX-826) showed hair growth in Chinese Phase III trials but did not significantly outperform placebo. The treatment was safe with no major adverse reactions reported.

community Selling KY19382 powder a novel activator of Wnt/β-catenin signaling Product

in Product 2 upvotes 4 years ago

Selling KY19382 powder, a novel activator of Wnt/β-catenin signaling, and Kolliphor EL liquid for vehicle formulation. KY19382 is a growth agonist.

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