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    Glossary KLF4

    transcription factor regulating cell growth and differentiation

    KLF4, or Kruppel-like factor 4, is a protein that plays a crucial role in regulating cell growth, differentiation, and maintaining stem cell pluripotency. It is involved in various biological processes, including skin and hair follicle development, and has been studied for its potential implications in cancer and regenerative medicine.

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    1. The Tissue-dependent Keratin 19 Gene Transcription Is Regulated by GKLF/KLF4 and Sp1 Journal of Biological Chemistry · 2000 · 119 citations
    2. WNT10A mutation causes ectodermal dysplasia by impairing progenitor cell proliferation and KLF4-mediated differentiation Nature Communications · 2017 · 96 citations
    3. Expression of Kruppel-Like Factor KLF4 in Mouse Hair Follicle Stem Cells Contributes to Cutaneous Wound Healing PLOS ONE · 2012 · 23 citations
    4. Function of KLF4 in Stem Cell Biology InTech eBooks · 2013 · 5 citations
    5. 1438 KLF4 maintains hair follicle stem cell quiescence 2023
    6. Effect of overexpression of KLF4 on the growth and development of hair follicles in mice Development Genes and Evolution · 2023 · 2 citations
    7. MicroRNA-302 Increases Reprogramming Efficiency via Repression of NR2F2 Stem cells · 2012 · 123 citations
    8. Induced Pluripotent Stem Cells from Human Hair Follicle Mesenchymal Stem Cells Stem Cell Reviews and Reports · 2012 · 64 citations
    9. IL-36γ drives skin toxicity induced by EGFR/MEK inhibition and commensal Cutibacterium acnes 2019 · 32 citations
    10. Induced pluripotent stem cells from human hair follicle keratinocytes as a potential source for <i>in vitro</i> hair follicle cloning PeerJ · 2016 · 18 citations
    11. Lithium chloride promotes the odontoblast differentiation of hair follicle neural crest cells by activating Wnt/β‐catenin signaling Cell Biology International · 2014 · 16 citations
    12. Generation of iPS Cells from Human Hair Follice Dermal Papilla Cells Acta naturae · 2014 · 15 citations
    13. A Kaleidoscope of Keratin Gene Expression and the Mosaic of Its Regulatory Mechanisms International journal of molecular sciences · 2023 · 3 citations
    14. Formation of the cornified envelope Experimental dermatology · 2005 · 3 citations
    15. Extracellular vesicles from 3D cultured dermal papilla cells improve wound healing via Krüppel-like factor 4/vascular endothelial growth factor A -driven angiogenesis Burns and trauma · 2023 · 1 citations
    16. When bugs and drugs conspire: driving acneiform skin toxicity 2020 · 1 citations
    17. Papulopustular eruptions associated with EGFR-pathway-related targeted therapies: clinical spectrum, evidence boundaries, folliculocentric inflammation, and management considerations Frontiers in Oncology · 2026
    18. 169 TEDAR, a skin-specific long non-coding RNA, orchestrates the late epidermal differentiation program in the human epidermis Journal of Investigative Dermatology · 2025
    19. Inhibition of the Hippo pathway by verteporfin reduces the proliferation and stemness of rat hair follicle neural crest stem cells under hypoxia FASEB BioAdvances · 2025
    20. Deciphering a Message from the Nucleus: How Transcription Factors and Spatial Chromatin Interactions Orchestrate Epidermal Differentiation 2023
    21. 1335 Maintenance of epidermal progenitor function through the mRNA degradation and translation pathways Journal of Investigative Dermatology · 2018
    22. The Role of ATP-dependent Chromatin Remodeling in the Control of Epidermal Differentiation and Skin Stem Cell Activity Stem cell biology and regenerative medicine · 2018
    23. Analysis of Sonic Hedgehog signalling pathway gene expression in Basal Cell Carcinoma and in GLII induced systems Queen Mary Research Online (Queen Mary University of London) · 2007
    24. The keratin 19 promoter is potent for cell-specific targeting of genes in transgenic mice Gastroenterology · 2001 · 66 citations
    25. Stem and cancer cells Wnt long telomeres Nature Cell Biology · 2012
    26. 905 Dysfunction of hair follicle mesenchymal progenitors is associated with age-related hair loss 2019
    27. Reprogramming of Human Hair Follicle Dermal Papilla Cells into Induced Pluripotent Stem Cells Journal of Investigative Dermatology · 2012 · 26 citations
    28. Synchronizing actin and microtubules for axonal branching Nature Cell Biology · 2012 · 3 citations
    29. Watching hair grow Nature Cell Biology · 2012
    30. Differentiation of Mouse Induced Pluripotent Stem Cells into a Multipotent Keratinocyte Lineage 2010 · 101 citations