Dermal Papilla Cells Improve Wound Healing and Generate Hair Bud-Like Structures in Grafted Skin Substitutes Using Hair Follicle Stem Cells

    August 2014 in “ Stem Cells Translational Medicine ”
    Gustavo José Leirós, Ana Gabriela Kusinsky, H. Drago … María Eugenia Balañá
    Studysummary This study found that composite skin constructs containing dermal papilla cells promoted better skin healing and hair regeneration in nude mice, highlighting their role in tissue-engineered skin for severe injuries.
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    Research cited in this study 16

    1. Dissociated Human Dermal Papilla Cells Induce Hair Follicle Neogenesis in Grafted Dermal-Epidermal Composites Journal of Investigative Dermatology · 2013
    2. Characterization of Hair Follicle Development in Engineered Skin Substitutes PLOS ONE · 2013
    3. Morphogenesis of Chimeric Hair Follicles in Engineered Skin Substitutes With Human Keratinocytes and Murine Dermal Papilla Cells Experimental Dermatology · 2012
    4. Hair Follicle Stem Cell Differentiation Is Inhibited Through Cross-Talk Between Wnt/β-Catenin and Androgen Signaling in Dermal Papilla Cells From Patients With Androgenetic Alopecia British Journal of Dermatology · 2012
    5. Tissue-Engineered Skin Preserving the Potential of Epithelial Cells to Differentiate into Hair After Grafting Tissue Engineering Part A · 2010
    6. The Mesenchymal Component of Hair Follicle Neogenesis: Background, Methods, and Molecular Characterization Experimental Dermatology · 2009
    7. Angiogenin Is Expressed in Human Dermal Papilla Cells and Stimulates Hair Growth Archives of dermatological research · 2008
    8. Multi-Potentiality of a New Immortalized Epithelial Stem Cell Line Derived from Human Hair Follicles In vitro cellular & developmental biology. Animal · 2008
    9. The Hair Cycle Journal of Cell Science · 2006
    10. Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis Nature Medicine · 2005
    11. Dermal Papilla-Induced Hair Differentiation of Adult Epithelial Stem Cells from Human Skin Physiological Genomics · 2004
    12. Molecular Control of Epithelial-Mesenchymal Interactions During Hair Follicle Cycling ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings · 2003
    13. Molecular Mechanisms Regulating Hair Follicle Development ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002
    14. Ability of Transplanted Cultured Epithelium to Respond to Dermal Papillae Tissue engineering · 2001
    15. The Chemotactic Effect of a Dermal Papilla Cell-Derived Factor on Outer Root Sheath Cells Journal of Dermatological Science · 2001
    16. Vascular Endothelial Growth Factor Is an Autocrine Growth Factor for Hair Dermal Papilla Cells Journal of Investigative Dermatology · 1996

    Related research 4

    1. The Role of YAP1 in Regeneration of Human Skin and in Pathological States ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2022
    2. Dermal Fibroblast Expression of LEF1 Is Critical to Normal Skin and Hair Development and Regenerative Wound Healing in Mice Journal of Investigative Dermatology · 2022
    3. Wound Healing and Skin Regeneration Cold Spring Harbor Perspectives in Medicine · 2015
    4. Reconstructed Tissue-Engineered Skin with ES Cell-Derived Epidermal Stem Cells and Collagen Sponge Journal of Sun Yat-sen University · 2006