Dermal Papilla Cells Improve Wound Healing and Generate Hair Bud-Like Structures in Grafted Skin Substitutes Using Hair Follicle Stem Cells

    August 2014 in “ Stem Cells Translational Medicine ”
    Gustavo José Leirós, Ana Gabriela Kusinsky, H. Drago, Silvia Bossi, F. Sturla, María Lía Castellanos, Inés Stella, María Eugenia Balañá
    Image of study
    TLDR Dermal papilla cells help wounds heal better and can potentially grow new hair.
    In 2014, a study was conducted to investigate the role of dermal papilla cells (DPCs) and hair follicle stem cells (HFSCs) in wound healing and hair regeneration. The study found that skin constructs containing DPCs showed improved wound healing and potential for hair follicle neogenesis. These constructs had a more regular stratification pattern, a higher number of p63-positive basal epidermal cells (indicating an improved precursor cell reservoir), and a higher number of blood vessels. Only constructs with DPCs formed hair bud-like structures, suggesting potential for hair growth. The study concluded that DPCs not only improve the wound healing process but also contribute to hair growth.
    Discuss this study in the Community →

    Research cited in this study

    10 / 10 results

    Related Community Posts Join

    6 / 1000+ results

      community Fats on your Head to Stop Hair Loss?

      in Research/Science  142 upvotes 10 months ago
      The conversation discusses the potential of long-chain unsaturated fatty acids, like oleic and linoleic acid, as an additional treatment for hair loss, which may inhibit the enzyme responsible for converting testosterone to DHT and promote hair growth. Users humorously suggest using oils topically and discuss other hair loss treatments, but the main focus is on the science behind fatty acids and their role in hair health.

      community New and Interesting HairLoss Studies/Papers/Reviews

      in Treatment  42 upvotes 4 years ago
      Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 4 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Keratin microspheres - breakthrough

      in Research/Science  13 upvotes 9 months ago
      A gel of keratin microspheres promotes hair follicle growth, showing similar effectiveness to minoxidil in mice. The treatment activates hair growth pathways and reduces inflammation, with potential applications in drug delivery for hair-related disorders.

      community The theory that explains everything. Please help me make this big!

      in Research/Science  2447 upvotes 3 years ago
      The post and conversation are about the role of the enzyme 3alpha-hydroxysteroid reductase in hair loss and the potential of compounds like procyanidin B2 and sulforaphane to boost its activity for hair regrowth. Further research is needed to develop effective treatments based on this theory.

    Related Research

    3 / 3 results