Dermal Papilla Cells Improve Wound Healing and Generate Hair Bud-Like Structures in Grafted Skin Substitutes Using Hair Follicle Stem Cells

    August 2014 in “ Stem Cells Translational Medicine ”
    Gustavo José Leirós, Ana Gabriela Kusinsky, H. Drago, Silvia Bossi, F. Sturla, María Lía Castellanos, Inés Stella, María Eugenia Balañá
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    TLDR Dermal papilla cells help wounds heal better and can potentially grow new hair.
    In 2014, a study was conducted to investigate the role of dermal papilla cells (DPCs) and hair follicle stem cells (HFSCs) in wound healing and hair regeneration. The study found that skin constructs containing DPCs showed improved wound healing and potential for hair follicle neogenesis. These constructs had a more regular stratification pattern, a higher number of p63-positive basal epidermal cells (indicating an improved precursor cell reservoir), and a higher number of blood vessels. Only constructs with DPCs formed hair bud-like structures, suggesting potential for hair growth. The study concluded that DPCs not only improve the wound healing process but also contribute to hair growth.
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