The Role of YAP1 in Regeneration of Human Skin and in Pathological States

The study developed a full-layer human skin xenograft model to investigate the role of YAP1 in skin regeneration. By day 110 post-transplantation, most dermal processes normalized, but the epidermis remained thickened with hypertrophic basal keratinocytes. Initially, YAP1 distribution in the xenograft resembled chronic wounds, with low epidermal expression and high nuclear localization in fibroblasts. By day 110, it resembled cutaneous papilloma, with YAP1 present in most basal layer nuclei. These findings suggest that YAP1's regulation of differentiation and proliferation may influence skin xenograft regeneration, indicating its potential as a target for treating skin pathologies.