Application of Cell-Derived Extracellular Vesicles and Engineered Nanovesicles for Hair Growth: From Mechanisms to Therapeutics

July 2022 in “ Frontiers in cell and developmental biology ”

Prakash Gangadaran, Ramya Lakshmi Rajendran, Mi Hee Kwack, Madhan Jeyaraman, Chae Moon Hong, Young Kwan Sung, Byeong‐Cheol Ahn

cell-derived nanovesicles extracellular vesicles proteins lipids nucleic acids endogenous materials exogenous drugs regenerative purposes hair growth hair loss CDVs EVs

TLDR Tiny natural vesicles from cells might help treat hair loss.

Recent studies have indicated that cell-derived nanovesicles (CDVs), which are natural extracellular vesicles capable of carrying biological materials like proteins, lipids, and nucleic acids, may offer new treatment strategies for hair growth. These vesicles can interact with cells both locally and at a distance, potentially delivering both endogenous materials and exogenous drugs for regenerative purposes. The review discusses the current understanding of how CDVs can be applied to hair growth and suggests that a deeper knowledge of their mechanisms could hasten their clinical application for treating hair loss.

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research Exosomal miRNA-181a-5p from Hair Follicle Dermal Papilla Cells Promotes Hair Follicle Growth and Development via the Wnt/β-Catenin Signaling Pathway

25 citations , May 2022 in “International journal of biological macromolecules”

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5 citations , March 2022 in “Frontiers in Cell and Developmental Biology”

research Exosomes Secreted from Adipose-Derived Stem Cells Are a Potential Treatment Agent for Immune-Mediated Alopecia

6 citations , February 2022 in “Journal of immunology research”

Exosomes from fat-derived stem cells can potentially improve hair growth and could be a new treatment for immune-related hair loss.

research Tissue Engineering and Regeneration of the Human Hair Follicle in Androgenetic Alopecia: Literature Review

4 citations , January 2022 in “Life”

Tissue engineering could be a future solution for hair loss, but it's currently expensive, complex, and hard to apply in real-world treatments.

research Dermal Papilla Cell-Derived Extracellular Vesicles Increase Hair Inductive Gene Expression in Adipose Stem Cells via β-Catenin Activation

12 citations , January 2022 in “Cells”

Dermal papilla cell vesicles can boost hair growth genes in fat stem cells.

research Engineered Extracellular Vesicle Mimetics from Macrophage Promotes Hair Growth in Mice and Human Hair Follicle Growth

8 citations , December 2021 in “Experimental cell research”

Engineered vesicles from macrophages help hair growth in mice and humans.

research Platelet-Rich Plasma and Cell Therapy

11 citations , July 2021 in “Dermatologic clinics”

PRP and cell therapies may help with hair loss, but more research is needed.

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42 citations , February 2021 in “Signal Transduction and Targeted Therapy”

Hair follicle regeneration possible, more research needed.

research Neural Progenitor Cell-Derived Nanovesicles Promote Hair Follicle Growth via miR-100

29 citations , January 2021 in “Journal of nanobiotechnology”

Tiny particles from brain cells help hair grow by targeting a specific hair growth pathway.

research MiR-140-5p in Small Extracellular Vesicles From Human Papilla Cells Stimulates Hair Growth by Promoting Proliferation of Outer Root Sheath and Hair Matrix Cells

18 citations , December 2020 in “Frontiers in cell and developmental biology”

miR-140-5p in certain cell vesicles helps hair growth by boosting cell proliferation.

research Dermal Exosomes Containing miR-218-5p Promote Hair Regeneration by Regulating β-Catenin Signaling

65 citations , July 2020 in “Science Advances”

Dermal exosomes with miR-218-5p boost hair growth by controlling β-catenin signaling.

research Migration Inhibitory Factor in Conditioned Medium from Human Umbilical Cord Blood-Derived Mesenchymal Stromal Cells Stimulates Hair Growth

19 citations , May 2020 in “Cells”

Substance from human umbilical cord blood cells promotes hair growth.

research Systematic Review of Platelet-Rich Plasma Use in Androgenetic Alopecia Compared with Minoxidil, Finasteride, and Adult Stem Cell-Based Therapy

65 citations , April 2020 in “International Journal of Molecular Sciences”

PRP injections may be a safe, effective alternative for hair loss treatment compared to minoxidil and finasteride.

research Macrophage-Derived Extracellular Vesicle Promotes Hair Growth

51 citations , April 2020 in “Cells”

Special cell particles from macrophages can help hair grow.

research The Potential of a Hair Follicle Mesenchymal Stem Cell-Conditioned Medium for Wound Healing and Hair Follicle Regeneration

6 citations , April 2020 in “Applied sciences”

Hair growth medium helps heal wounds and regrow hair in mice.

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The review concluded that keeping the hair-growing ability of human dermal papilla cells is key for hair development and growth.

research Sustained Release of Dermal Papilla-Derived Extracellular Vesicles from Injectable Microgel Promotes Hair Growth

46 citations , January 2020 in “Theranostics”

Injecting a special gel with human protein particles can help hair grow.

research Exosome for Hair Regeneration: From Bench to Bedside

9 citations , October 2019 in “Journal of the American Academy of Dermatology”

Exosomes from stem cells may help treat hair loss.

research Exosomes Derived from Human Dermal Papilla Cells Promote Hair Growth in Cultured Human Hair Follicles and Augment the Hair-Inductive Capacity of Cultured Dermal Papilla Spheres

58 citations , July 2019 in “Experimental Dermatology”

Exosomes from human skin cells can stimulate hair growth and could potentially be used for treating hair loss.

research Extracellular Vesicles from Activated Dermal Fibroblasts Stimulate Hair Follicle Growth Through Dermal Papilla-Secreted Norrin

37 citations , June 2019 in “Stem cells”

Special particles from skin cells can promote hair growth by activating a specific growth signal.

research A Therapeutic Microneedle Patch Made from Hair-Derived Keratin for Promoting Hair Regrowth

192 citations , April 2019 in “ACS nano”

A new microneedle patch made from hair proteins helps regrow hair faster and better than current treatments.

research Exosomal MicroRNAs Derived from Dermal Papilla Cells Mediate Hair Follicle Stem Cell Proliferation and Differentiation

71 citations , January 2019 in “International journal of biological sciences”

Exosomes from dermal papilla cells help hair growth by making hair follicle stem cells multiply and change.

research A Randomized, Double-Blind Controlled Study of the Efficacy and Safety of Topical Solution of 0.25% Finasteride Admixed with 3% Minoxidil vs. 3% Minoxidil Solution in the Treatment of Male Androgenetic Alopecia

43 citations , December 2018 in “Journal of The European Academy of Dermatology and Venereology”

Finasteride and minoxidil mix works better for hair growth than minoxidil alone, with similar safety.

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87 citations , June 2018 in “Biochemical and Biophysical Research Communications”

Exosomes from dermal papilla cells can help grow hair and might treat hair loss.

research Extracellular Vesicles Derived from MSCs Activate Dermal Papilla Cells In Vitro and Promote Hair Follicle Conversion from Telogen to Anagen in Mice

113 citations , November 2017 in “Scientific Reports”

Tiny particles from stem cells help activate hair growth cells and encourage hair growth in mice without being toxic.

research Hair Regeneration Therapy: Application of Adipose-Derived Stem Cells

55 citations , September 2017 in “Current stem cell research & therapy”

Using fat-derived stem cells for hair loss treatment is safe and effective, improving hair growth and patient satisfaction.

research Diet and Hair Loss: Effects of Nutrient Deficiency and Supplement Use

79 citations , January 2017 in “Dermatology practical & conceptual”

Correcting nutrient deficiencies may help with hair loss, but the benefits of supplements without a deficiency are uncertain and could be harmful.

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212 citations , January 2016 in “Journal of Investigative Dermatology”

The document provides a method to classify human hair growth stages using a model with human scalp on mice, aiming to standardize hair research.

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53 citations , March 2014 in “Cold Spring Harbor Perspectives in Medicine”

The document explains different types of hair loss, their causes, and treatments, and suggests future research areas.

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179 citations , April 2012 in “Nature Communications”

Regenerated fully functional hair follicles using stem cells, with potential for hair regrowth therapy.

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66 citations , July 2010 in “Experimental Dermatology”

The hair follicle is a great model for research to improve hair growth treatments.