Engineered Extracellular Vesicle Mimetics from Macrophage Promotes Hair Growth in Mice and Human Hair Follicle Growth

October 2021 in “ Experimental cell research ”

Ramya Lakshmi Rajendran, Prakash Gangadaran, Mi Hee Kwack, Ji Min Oh, Chae Moon Hong, Arunnehru Gopal, Young Kwan Sung, Jaetae Lee, Byeong‐Cheol Ahn

engineered extracellular vesicle mimetics macrophage hair regrowth hair follicle growth dermal papilla cells signaling pathways hair regeneration hair follicle cycle EMs MAC-EMs DP cells

Studysummary This study found that macrophage-engineered extracellular vesicle mimetics may promote hair regrowth, presenting a potential alternative to extracellular vesicles for overcoming clinical production challenges.

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This study demonstrates that engineered extracellular vesicle mimetics (EMs) derived from macrophages (MAC-EMs) can effectively promote hair regrowth in mice and enhance hair follicle growth in human samples. MAC-EMs were shown to increase the proliferation of dermal papilla (DP) cells and activate various signaling pathways, leading to improved hair regeneration by regulating the hair follicle cycle. The findings suggest that MAC-EMs are promising candidates for large-scale production and potential therapeutic use in treating hair loss in humans.

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