Neural Progenitor Cell-Derived Nanovesicles Promote Hair Follicle Growth via miR-100

The study demonstrated that neural progenitor cell-derived nanovesicles (ReN-NV) significantly promoted hair follicle growth by delivering miR-100 to dermal papilla cells (DPCs), which activated the Wnt/β-catenin signaling pathway. This led to increased expression of β-catenin, C-myc, and Cyclin D1, enhancing DPC proliferation and accelerating the transition from telogen to anagen phase in hair follicles. In vivo experiments with C57BL/6 mice confirmed these findings, showing that ReN-NV injections led to earlier anagen entry and increased hair follicle growth compared to controls. The study suggested that ReN-NV could be a promising strategy for treating non-scarring alopecia and improving hair growth therapies.