Neural Progenitor Cell-Derived Nanovesicles Promote Hair Follicle Growth via miR-100

    January 2021 in “ Journal of nanobiotechnology
    Lei Cao, Tian Tian, Yuanbo Huang, Shiqin Tao, Xiaodong Zhu, Mingxia Yang, Jing Gu, Guangdong Feng, Yinni Ma, Rushan Xia, Xu Wang, Lei Wang
    TLDR Tiny particles from brain cells help hair grow by targeting a specific hair growth pathway.
    The study demonstrated that neural progenitor cell-derived nanovesicles (ReN-NV) significantly promoted hair follicle growth by delivering miR-100 to dermal papilla cells (DPCs), which activated the Wnt/β-catenin signaling pathway. This led to increased expression of β-catenin, C-myc, and Cyclin D1, enhancing DPC proliferation and accelerating the transition from telogen to anagen phase in hair follicles. In vivo experiments with C57BL/6 mice confirmed these findings, showing that ReN-NV injections led to earlier anagen entry and increased hair follicle growth compared to controls. The study suggested that ReN-NV could be a promising strategy for treating non-scarring alopecia and improving hair growth therapies.
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