Neural Progenitor Cell-Derived Nanovesicles Promote Hair Follicle Growth via miR-100

August 2020 in “ Research Square (Research Square) ”

Lei Cao, Tian Tian, Yuanbo Huang, Shiqin Tao, Xiaohong Zhu, Mingxia Yang, Jing Gu, Guangdong Feng, Yinni Ma, Rushan Xia, Wenrong Xu, Lei Wang

neural progenitor cell-derived nanovesicles ReN-NV hair follicle growth dermal papilla cell proliferation hair follicle cycling Wnt/β-catenin signaling pathway miR-100 extracellular vesicles nanovesicles hair growth Wnt signaling microRNA-100 EVs

TLDR Neural progenitor cell-derived nanovesicles help hair growth by activating a key signaling pathway.

The study demonstrated that neural progenitor cell-derived nanovesicles (ReN-NV) promoted hair follicle growth by enhancing dermal papilla cell proliferation and accelerating hair follicle cycling in a mouse model. The mechanism involved the activation of the Wnt/β-catenin signaling pathway, with miR-100 playing a crucial role in this process. These findings suggested that ReN-NV could serve as an effective alternative to extracellular vesicles for hair growth therapy.

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