Differential Expression of Proteins Associated with the Hair Follicle Cycle: Proteomics and Bioinformatics Analyses

In the 2016 study by Wang et al., researchers analyzed the differential expression of proteins associated with the hair follicle cycle in mice using proteomics and bioinformatics. They identified 44 proteins with varying expression across the anagen, catagen, and telogen stages, which were involved in processes such as calcium regulation, migration, and signal transduction. The proteins were grouped into clusters corresponding to the hair cycle stages and were found to be part of multiple biological networks, with functions related to apoptosis, proliferation, signal transduction, and other cellular processes. The study confirmed the expression patterns of selected proteins and suggested that these proteins play significant roles in the biological networks during the hair follicle cycle, especially in the anagen stage crucial for hair growth. The study also highlighted the potential of certain proteins, like Tpt1, as candidates for studying cell reprogramming mechanisms, despite challenges in analyzing some proteins due to their properties. The number of mice used in the study was not specified.