Impact of Taxol on Dermal Papilla Cells: A Proteomics and Bioinformatics Analysis

The study investigated the effects of taxol, a chemotherapy drug, on dermal papilla (DP) cells, which are crucial for hair growth and implicated in alopecia. The research demonstrated that taxol induced apoptosis in DP cells in a concentration-dependent manner. Proteomic analysis revealed that taxol affected the expression of proteins involved in various biological processes, including Ca2+ regulation, vesicle transport, protein folding, detoxification, and metabolism. Bioinformatics analysis further indicated that taxol impacted multiple biological networks. These findings provided insights into the mechanisms of taxol-induced damage in DP cells and the underlying causes of taxol-induced alopecia.