Irradiation-Induced Hair Graying in Mice: An Experimental Model to Evaluate the Effectiveness of Interventions Targeting Oxidative Stress, DNA Damage Prevention, and Cellular Senescence

    January 2024 in “ GeroScience ”
    Anna Ungvari, Tamás Kiss, Rafał Gulej … Zoltán Ungvári
    Studysummary This review explores how radiation-induced hair graying can be used as a model to study the mechanisms behind hair graying, focusing on cellular senescence and potential therapeutic targets to address age-related changes. Results are not provided.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on link.springer.com →
    Discuss this study in the Community →

    Research cited in this study 40

    1. Recent Omics Advances In Hair Aging Biology And Hair Biomarkers Analysis Ageing Research Reviews · 2023
    2. Clinical Pathobiology of Radiotherapy-Induced Alopecia: A Guide Toward More Effective Prevention and Hair Follicle Repair ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2023
    3. BMI1 Is Required for Melanocyte Stem Cell Maintenance and Hair Pigmentation Pigment Cell & Melanoma Research · 2023
    4. Innovative Approaches and Advances for Hair Follicle Regeneration ACS Biomaterials Science & Engineering · 2023
    5. Understanding Mammalian Hair Follicle Ecosystems by Single-Cell RNA Sequencing Animals · 2022
    6. Toward Elucidating Epigenetic and Metabolic Regulation of Stem Cell Lineage Plasticity in Skin Aging Frontiers in Cell and Developmental Biology · 2022
    7. Hair Graying Regulators Beyond Hair Follicle Frontiers in physiology · 2022
    8. An Efficient, Non-Invasive Approach for In Vivo Sampling of Hair Follicles: Design and Applications in Monitoring DNA Damage and Aging Aging · 2021
    9. Stress-Sensing in the Human Greying Hair Follicle: Ataxia Telangiectasia Mutated (ATM) Depletion in Hair Bulb Melanocytes in Canities-Prone Scalp Scientific reports · 2020
    10. Exploring the Possibility of Predicting Human Head Hair Greying from DNA Using Whole-Exome and Targeted NGS Data BMC Genomics · 2020
    11. Premature Graying of Hair: Risk Factors, Co-Morbid Conditions, Pharmacotherapy and Reversal—A Systematic Review and Meta-Analysis Dermatologic therapy · 2020
    12. Topical RT1640 Treatment Effectively Reverses Gray Hair and Stem Cell Loss in a Mouse Model of Radiation-Induced Canities Pigment cell & melanoma research · 2020
    13. Hyperactivation of Sympathetic Nerves Drives Depletion of Melanocyte Stem Cells Nature · 2020
    14. Medication-Induced Repigmentation of Gray Hair: A Systematic Review Skin appendage disorders · 2019
    15. Reversing Wrinkled Skin and Hair Loss in Mice by Restoring Mitochondrial Function Cell death and disease · 2018
    16. Association of Epidemiological and Biochemical Factors with Premature Graying of Hair: A Case-Control Study International journal of trichology · 2018
    17. Three Streams for the Mechanism of Hair Graying Annals of dermatology/Annals of Dermatology · 2018
    18. Caloric Restriction Promotes Structural and Metabolic Changes in the Skin Cell Reports · 2017
    19. Oxidative Stress Management in the Hair Follicle: Could Targeting NRF2 Counter Age-Related Hair Disorders and Beyond? BioEssays · 2017
    20. Identification of Hair Shaft Progenitors That Create a Niche for Hair Pigmentation Genes & development · 2017
    21. EdnrB Governs Regenerative Response of Melanocyte Stem Cells by Crosstalk with Wnt Signaling Cell Reports · 2016
    22. A Genome-Wide Association Scan in Admixed Latin Americans Identifies Loci Influencing Facial and Scalp Hair Features Nature Communications · 2016
    23. Association of Premature Hair Graying with Family History, Smoking, and Obesity: A Cross-Sectional Study Journal of The American Academy of Dermatology · 2014
    24. Resting No More: Redefining Telogen, the Maintenance Stage of the Hair Growth Cycle Biological Reviews · 2014
    25. Age-Related Hair Changes in Men: Mechanisms and Management of Alopecia and Graying Maturitas · 2014
    26. Defects in Mitochondrial DNA Replication and Oxidative Damage in Muscle of mtDNA Mutator Mice Free radical biology & medicine · 2014
    27. Premature Graying as a Consequence of Compromised Antioxidant Activity in Hair Bulb Melanocytes and Their Precursors PLOS ONE · 2014
    28. Cell and Tissue Damage After Skin Exposure to Ionizing Radiation: Short- and Long-Term Effects After Single and Fractional Doses Cells Tissues Organs · 2014
    29. Age-Induced Hair Greying: The Multiple Effects of Oxidative Stress International Journal of Cosmetic Science · 2013
    30. Keratinocyte Stem Cells but Not Melanocyte Stem Cells Are the Primary Target for Radiation-Induced Hair Graying Journal of Investigative Dermatology · 2013
    31. Deficiency in Nucleotide Excision Repair Family Gene Activity, Especially ERCC3, Is Associated with Non-Pigmented Hair Fiber Growth PloS one · 2012
    32. Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration Cell · 2011
    33. Hair Follicle Stem Cells Provide a Functional Niche for Melanocyte Stem Cells Cell stem cell · 2011
    34. A Neuroendocrinological Perspective on Human Hair Follicle Pigmentation Pigment Cell & Melanoma Research · 2010
    35. Senile Hair Graying: H2O2-Mediated Oxidative Stress Affects Human Hair Color by Blunting Methionine Sulfoxide Repair The FASEB Journal · 2009
    36. Analyses of Regenerative Wave Patterns in Adult Hair Follicle Populations Reveal Macro-Environmental Regulation of Stem Cell Activity ˜The œInternational journal of developmental biology · 2009
    37. Towards A Free Radical Theory Of Graying: Melanocyte Apoptosis In The Aging Human Hair Follicle As An Indicator Of Oxidative Stress Induced Tissue Damage ˜The œFASEB journal · 2006
    38. Melanocyte Stem Cell Maintenance and Hair Graying Cell · 2005
    39. Do Hair Bulb Melanocytes Undergo Apoptosis During Hair Follicle Regression (Catagen)? ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1998
    40. Melanogenesis During the Anagen-Catagen-Telogen Transformation of the Murine Hair Cycle ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1994