Protective Effect of Conditioned Medium of Immortalized Human Stem Cells from Exfoliated Deciduous Teeth Against Hair Graying Caused by X-Ray Irradiation via Its Antioxidative Activity

January 2025 in “ Antioxidants ”

Yasuhiro Katahira, Eri Horio, Natsuki Yamaguchi, Jukito Sonoda, Miu Yamagishi, Satomi Miyakawa, Fumihiro Murakami, Hideaki Hasegawa, Izuru Mizoguchi, Takayuki Yoshimoto

conditioned medium immortalized human stem cells exfoliated deciduous teeth SHED-CM hair graying X-ray irradiation antioxidative activity hepatocyte growth factor HGF vascular endothelial growth factor VEGF oxidative stress stem cell conditioned medium SHED hair whitening radiation exposure antioxidant growth factors

TLDR SHED-CM can reduce hair graying and protect against damage from X-rays.

The study explores the protective effects of conditioned medium from immortalized human stem cells from exfoliated deciduous teeth (SHED-CM) against hair graying caused by X-ray irradiation in mice. Repeated administrations of SHED-CM significantly reduced hair graying and oxidative stress, attributed to its antioxidative activity involving hepatocyte growth factor (HGF) and possibly vascular endothelial growth factor (VEGF). SHED-CM also protected cells from X-ray-induced damage, suggesting its potential as a therapeutic agent for preventing hair graying and protecting against oxidative damage. Further research is needed to optimize its application and ensure safety.

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Research cited in this study

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research Establishment and Characterization of Matched Immortalized Human Frontal and Occipital Scalp Dermal Papilla Cell Lines from Androgenetic Alopecia

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Dermal Papilla Cells: From Basic Research to Translational Applications

Protective Effect of Conditioned Medium of Immortalized Human Stem Cells from Exfoliated Deciduous Teeth Against Hair Graying Caused by X-Ray Irradiation via Its Antioxidative Activity

Research cited in this study

research Irradiation-Induced Hair Graying in Mice: An Experimental Model to Evaluate the Effectiveness of Interventions Targeting Oxidative Stress, DNA Damage Prevention, and Cellular Senescence

research Stem Cell Secretome as a Mechanism for Restoring Hair Loss Due to Stress, Particularly Alopecia Areata: Narrative Review

research Application of Cell-Derived Extracellular Vesicles and Engineered Nanovesicles for Hair Growth: From Mechanisms to Therapeutics

research Advancing Regenerative Cellular Therapies in Non-Scarring Alopecia

research Hair Graying Regulators Beyond Hair Follicle

research Medication-Induced Repigmentation of Gray Hair: A Systematic Review

research Molecular Mechanisms Responsible for Therapeutic Potential of Mesenchymal Stem Cell-Derived Secretome

research Mesenchymal Stromal Cell Secretome: Influencing Therapeutic Potential by Cellular Pre-Conditioning

research Mesenchymal Stem Cell Secretome: Toward Cell-Free Therapeutic Strategies in Regenerative Medicine

research Age-Induced Hair Greying: The Multiple Effects of Oxidative Stress

research Keratinocyte Stem Cells but Not Melanocyte Stem Cells Are the Primary Target for Radiation-Induced Hair Graying

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