Protective Effect of Conditioned Medium of Immortalized Human Stem Cells from Exfoliated Deciduous Teeth Against Hair Graying Caused by X-Ray Irradiation via Its Antioxidative Activity

January 2025 in “ Antioxidants ”

Yasuhiro Katahira, Eri Horio, Natsuki Yamaguchi, Jukito Sonoda, Miu Yamagishi, Satomi Miyakawa, Fumihiro Murakami, Hideaki Hasegawa, Izuru Mizoguchi, Takayuki Yoshimoto

conditioned medium immortalized human stem cells exfoliated deciduous teeth SHED-CM hair graying X-ray irradiation antioxidative activity hepatocyte growth factor HGF vascular endothelial growth factor VEGF oxidative stress stem cell conditioned medium SHED hair whitening radiation exposure antioxidant growth factors

TLDR SHED-CM can reduce hair graying and protect against damage from X-rays.

The study explores the protective effects of conditioned medium from immortalized human stem cells from exfoliated deciduous teeth (SHED-CM) against hair graying caused by X-ray irradiation in mice. Repeated administrations of SHED-CM significantly reduced hair graying and oxidative stress, attributed to its antioxidative activity involving hepatocyte growth factor (HGF) and possibly vascular endothelial growth factor (VEGF). SHED-CM also protected cells from X-ray-induced damage, suggesting its potential as a therapeutic agent for preventing hair graying and protecting against oxidative damage. Further research is needed to optimize its application and ensure safety.

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