Small Extracellular Vesicles From Mesenchymal Stem Cells: A Potential Weapon for Chronic Non-Healing Wound Treatment

    January 2023 in “ Frontiers in Bioengineering and Biotechnology ”
    Wei Qian, Xi Liu, Jianlong Su … Cuiping Zhang
    Studysummary This review discusses the therapeutic potential of mesenchymal stem cell-derived small extracellular vesicles for chronic wound treatment and reports no new clinical results, emphasizing the need for further research on their large-scale production and engineering.
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    Research cited in this study 9

    1. Application of Extracellular Vesicles From Mesenchymal Stem Cells Promotes Hair Growth by Regulating Human Dermal Cells and Follicles World journal of stem cells · 2022
    2. Photobiomodulation Promotes Hair Regeneration in Injured Skin by Enhancing Migration and Exosome Secretion of Dermal Papilla Cells Wound repair and regeneration · 2021
    3. Macrophage Related Chronic Inflammation in Non-Healing Wounds Frontiers in Immunology · 2021
    4. Applications of Mesenchymal Stem Cells in Skin Regeneration and Rejuvenation International Journal of Molecular Sciences · 2021
    5. Dermal Exosomes Containing miR-218-5p Promote Hair Regeneration by Regulating β-Catenin Signaling Science Advances · 2020
    6. Human Bone Marrow Mesenchymal Stem Cell-Derived Exosomes Stimulate Cutaneous Wound Healing Mediated Through TGF-β/Smad Signaling Pathway Stem Cell Research & Therapy · 2020
    7. Hopes and Limits of Adipose-Derived Stem Cells and Mesenchymal Stem Cells in Wound Healing International journal of molecular sciences · 2020
    8. Wound Healing: A Cellular Perspective Physiological Reviews · 2018
    9. A Conditioned Medium of Umbilical Cord Mesenchymal Stem Cells Overexpressing Wnt7a Promotes Wound Repair and Regeneration of Hair Follicles in Mice Stem Cells International · 2017