Photobiomodulation Promotes Hair Regeneration in Injured Skin by Enhancing Migration and Exosome Secretion of Dermal Papilla Cells

December 2021 in “ Wound repair and regeneration ”

Yuehou Zhang, Jianlong Su, Kui Ma, Haihong Li, Xiaobing Fu, Cuiping Zhang

photobiomodulation hair regeneration dermal papilla cells Sox9 PCNA exosome secretion Akt/GSK-3β/β-catenin pathway AKT inhibitor PBM DPCs

TLDR Photobiomodulation helps hair regrow in injured skin by aiding cell movement and secretion.

The study investigates the effects of photobiomodulation (PBM) on hair regeneration in injured skin using C57 mice. It was found that while scratched epidermis did not affect hair regeneration, scratched dermis led to hair follicle atrophy and impaired hair regeneration. PBM treatment (655 nm, 3 J/cm² for 10 minutes) significantly enhanced hair coverage and increased the presence of Sox9+ and PCNA+ cells in hair follicles. In vitro, PBM increased the migration but not the proliferation of dermal papilla cells (DPCs) and promoted exosome secretion via the Akt/GSK-3β/β-catenin pathway. The use of an AKT inhibitor blocked these effects, suggesting that PBM promotes hair regeneration through enhanced migration and exosome secretion of DPCs mediated by this pathway.

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