Review of Treatment for Alopecia Totalis and Alopecia Universalis

    Sama Kassira, Dorota Z. Korta, Lance W. Chapman, Francis Dann
    TLDR No treatment is completely effective for alopecia totalis and alopecia universalis.
    The review examined treatments for alopecia totalis (AT) and alopecia universalis (AU), focusing on evidence from 40 studies retrieved from PubMed between 2000 and 2016. Treatments included topical immunotherapy, steroids, photodynamic therapy, immunosuppressive agents, TNFα inhibitors, and other therapies like sulfasalazine, bexarotene, JAK inhibitors, and simvastatin/ezetimibe. While some treatments showed significant hair regrowth, none were completely effective. The most promising therapies were diphenylcyclopropenone, squaric acid dibutylester, photodynamic therapy, steroids, and cyclosporine with methylprednisolone. The review highlighted the need for high-quality randomized-controlled trials with large sample sizes and unified outcome guidelines to better compare future studies.
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