Combination Therapy With Oral PUVA and Corticosteroid for Recalcitrant Alopecia Areata

    March 2009 in “ Archives of dermatological research ”
    Taisuke Ito, Masahiro Aoshima, Natsuho Ito, Izumi Uchiyama, Keiko Sakamoto, Tetsuya Kawamura, Hiroaki Yanagimoto, Hideo Hashizume, Masaharu Takigawa
    TLDR The combination of oral PUVA and corticosteroids helps regrow hair in severe alopecia areata.
    The study investigated the effectiveness of a combination therapy using oral corticosteroids and oral PUVA for treating severe alopecia areata (AA), specifically alopecia totalis (AT) and alopecia universalis (AU). Patients received 20 mg/day of corticosteroids and whole-body UVA irradiation 2 hours after taking methoxsalen for 1 month. All patients experienced regrowth of terminal hair on the scalp within 2 months, although two patients relapsed 3 months post-treatment. The therapy increased the population of regulatory T cells (Tregs) and decreased the number of infiltrating cells in the skin lesions, suggesting an immune-modulating effect that contributed to the improvement of recalcitrant AA.
    Discuss this study in the Community →

    Research cited in this study

    4 / 4 results

    Related Community Posts Join

    6 / 1000+ results

      community Oral minoxidil timeframe (any late responders)

      in Minoxidil  21 upvotes 17 hours ago
      Oral minoxidil, finasteride, and dutasteride are being used to treat hair loss, but results are limited, leading to consideration of a hair transplant. The user plans to continue medication for another year before deciding on further action.

      community Oral minoxidil kullanan var mi?

      in General  122 upvotes 1 week ago
      The conversation is about finding a reliable source for oral minoxidil in Turkey, preferably in original packaging, and concerns about the safety and effectiveness of local products. The user is seeking recommendations for trustworthy suppliers and is wary of counterfeit products and scams.

      community Oral minoxidil - how important is dermastamping?

      in Microneedling 3 weeks ago
      A trans woman is using 10 mg oral minoxidil, dutasteride, and estradiol for hair regrowth and is also doing dermastamping despite the pain. Users discuss the benefits of dermastamping for serum absorption and hair follicle stimulation, with some expressing surprise at the high minoxidil dosage.

      community Oral Min Aging reversible?……..

      in Minoxidil 1 month ago
      Oral minoxidil may cause temporary facial puffiness, leading to a perception of accelerated aging, but it doesn't cause actual aging. Concerns about hair loss and treatments like minoxidil and finasteride are discussed, with suggestions to use tretinoin and sunscreen to mitigate potential side effects.

      community Treatment effectiveness for oral vs topical

      in Treatment  3 upvotes 1 month ago
      Oral treatments for hair loss, like Dutasteride and Minoxidil, may be more effective than topical ones, though topical formulations can be similarly effective except for Minoxidil. Topical treatments can be a chore to apply and are often used as supplements to oral treatments.

    Related Research

    3 / 3 results