Combined Oral Pulse and Topical Corticosteroid Therapy for Severe Alopecia Areata in Children: A Long-Term Follow-Up Study

    July 2015 in “ Dermatologic therapy ”
    Jovan Lalošević, Mirjana Gajić-Veljić, Branka Bonaci-Nikolic, Miloš Nikolić
    TLDR The combined therapy was effective and safe for children with severe alopecia areata.
    The study evaluated the effectiveness of combined oral pulse and topical corticosteroid therapy in 65 children with severe alopecia areata (AA) affecting more than 30% of the scalp. The treatment involved oral dexamethasone and clobetasol propionate ointment. After 6-12 months, 56.9% of patients experienced over 75% hair regrowth, with 65.5% of those with AA plurifocalis (AAP) achieving complete regrowth. Overall, 61.5% of patients were considered good responders, particularly those with AA lasting 12 months or less. Long-term follow-up (median 96 months) showed stable hair regrowth without serious side effects, indicating that this combined therapy was effective and safe for children with severe AA.
    Discuss this study in the Community →

    Research cited in this study

    12 / 12 results

    Related Community Posts Join

    6 / 1000+ results

      community This guy loses all transplanted hair?!

      in Transplants  160 upvotes 1 year ago
      A man lost his transplanted hair despite using minoxidil because he wasn't on a DHT blocker like finasteride, which is essential to prevent further hair loss. The conversation emphasizes that hair transplants are not a cure and require maintenance with medications to preserve results.

      community 10 months CB and Oral Minoxidil

      in Progress Pictures  114 upvotes 1 year ago
      A person with Alopecia Areata on their beard is using CB-03-01 and oral minoxidil for treatment. Some users question the effectiveness of CB-03-01 for beard hair, suggesting that minoxidil alone may be responsible for any observed hair growth.

      community 2 and 1/2 months, prescribed 1.25mg oral min daily

      in Progress Pictures  5 upvotes 1 month ago
      The user is treating alopecia areata with 1.25mg oral minoxidil daily and topical mometasone furoate, considering increasing the dose or adding finasteride, though finasteride is not typically used for this condition. A gluten-free diet is suggested, and alternatives like Olumiant are mentioned.

      community Rare Non responder to Finasteride, Dutasteride, and oral minoxidil

      in Minoxidil  78 upvotes 1 year ago
      A user did not respond to finasteride, dutasteride, and oral minoxidil for hair loss after four years of treatment and is considering scalp micropigmentation (SMP). Other users suggest the hair loss pattern may indicate alopecia areata and recommend seeing a dermatologist.

      community Second shed and more abnormalities

      in Treatment  1 upvotes 1 year ago
      The user has been using oral finasteride for 15 months and oral minoxidil for 6 months, and developed alopecia areata, for which a dermatologist prescribed calcipotriol/betamethasone. The treatment is helping, but the user is experiencing another shedding phase and is concerned about the effects of the steroid cream and the cause of hair loss.

    Related Research

    5 / 5 results