Pulse Corticosteroid Therapy for Alopecia Areata in Children: A Retrospective Study

    January 2013 in “ Dermatology ”
    Rivka Friedland, Rotem Tal, Moshe Lapidoth, Alex Zvulunov, Dan Ben Amitai
    TLDR Careful patient selection is key for effective pulse corticosteroid treatment in children with alopecia areata.
    This retrospective study investigated the effectiveness and side effects of intravenous high-dose pulse corticosteroids in 24 children with alopecia areata. The treatment involved 8 mg/kg body weight intravenous methylprednisolone administered over 3 consecutive days at 1-month intervals. Results showed that 38% of patients had a complete response, 29% had a partial response, and 33% had no response. Among responders, 81% relapsed within an average of 9.5 months. Side effects were noted in 3 patients but were not severe. Positive prognostic factors included short disease duration (≤6 months), younger age at onset (<10 years), and multifocal disease. The study concluded that careful patient selection is crucial for maximizing the benefits of pulse corticosteroid treatment in children with alopecia areata.
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