Placebo-Controlled Oral Pulse Prednisolone Therapy in Alopecia Areata

    February 2005 in “ Journal of the American Academy of Dermatology ”
    Bikash Ranjan Kar, Sanjeev Handa, Sunil Dogra, Bhushan Kumar
    TLDR Oral prednisolone helps hair regrowth in alopecia areata.
    This study evaluated the efficacy of weekly oral prednisolone pulse therapy in treating extensive alopecia areata (AA) through a placebo-controlled trial involving 43 patients. Group A, consisting of 23 patients, received 200 mg of oral prednisolone weekly, while Group B, with 20 patients, received placebo tablets. Over a 6-month period, significant hair regrowth was observed in 8 patients from the prednisolone group, although 2 experienced a relapse during the 3-month observation phase. No significant hair regrowth was noted in the placebo group. The study concluded that oral prednisolone pulse therapy was beneficial for AA, but further placebo-controlled studies with varied dosages were needed to optimize treatment efficacy and minimize side effects.
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