Alopecia Areata: Pathogenesis And Treatment

November 1984 in “ Journal of the American Academy of Dermatology ”

Andrew J. Mitchell, Edward A. Krull

alopecia areata autoimmune condition hair loss immune system dysfunction T-cell subpopulations cytotoxic activities systemic corticosteroids topical corticosteroids immunotherapy agents DNCB SADBE minoxidil photochemotherapy Rogaine

From the encyclopedia

Alopecia Areata →

autoimmune disorder causing patchy hair loss

Minoxidil →

An essential vasodilator with some anti-androgenic effects

Studysummary This review discusses the potential autoimmune pathogenesis and various contributing factors of alopecia areata, noting that current treatments remain palliative while emerging therapies offer new hope for extensive cases.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

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Research cited in this study

22 / 22 results

research Topical Treatment of Extended Alopecia

17 citations , October 2009 in “Dermatology”

This study reported that ultraviolet light treatment from a Kromayer lamp stimulated hair growth in four out of six patients with alopecia, whereas intralesional triamcinolone acetonide had a mixed effect.

research Intralesional Treatment of Alopecia Areata with Triamcinolone Acetonide by Jet Injector

100 citations , July 2006 in “British Journal of Dermatology”

This study found that intralesional triamcinolone acetonide injections using a needleless injector led to rapid hair regrowth in patients with limited alopecia areata, while lasting growth was rare in alopecia totalis.

research Alopecia Areata Treated With Topical Minoxidil

78 citations , April 1984 in “Archives of Dermatology”

This study found that 1% minoxidil topical solution led to terminal hair regrowth in some patients with alopecia areata, though it was only cosmetically acceptable in less than half of those cases.

research Topical Minoxidil in the Treatment of Alopecia Areata

80 citations , October 1983 in “BMJ”

This study found that 1% topical minoxidil induced significant hair regrowth in patients with alopecia areata, though it was less effective for those with extensive hair loss such as alopecia totalis and universalis.

research Photochemotherapy and Alopecia Areata

10 citations , May 1983 in “International Journal of Dermatology”

This study found that four out of ten patients with alopecia areata experienced some hair regrowth after PUVA therapy, though this treatment should be reserved for those unresponsive to other options due to potential long-term side effects.

research Diseases of the Hair and Scalp

January 1983 in “Journal of The American Academy of Dermatology”

The book is a valuable resource for understanding hair and scalp problems but could be updated with more information on certain conditions.

research Decreased Lymphocyte Reactivity and Autoimmunity in Alopecia Areata

54 citations , August 1981 in “British Journal of Dermatology”

This study found that patients with alopecia areata had significantly lower T cell numbers and reduced lymphocyte responses compared to healthy controls, correlated with hair loss severity and presence of antithyroid antibodies.

research Immunologic Studies in Patients With Alopecia Areata

5 citations , August 1981 in “Archives of Dermatology”

This paper examines the potential autoimmune basis of alopecia areata, but reports no new clinical results; the focus is on analyzing complement levels and macrophage migration inhibition factor in patients.

research Topical Minoxidil in Alopecia Areata

56 citations , August 1981 in “Journal of The American Academy of Dermatology”

Minoxidil helps hair regrowth in alopecia areata safely.

research Topical Treatment of Alopecia Areata

50 citations , July 1981 in “Archives of Dermatology”

This study found that applying dinitrochlorobenzene (DNCB), a contact allergen, led to hair regrowth in patients with alopecia areata, while croton oil did not have the same effect.

research Minoxidil

45 citations , January 1981 in “Annals of Internal Medicine”

Minoxidil controls blood pressure effectively, but may cause side effects like hypertrichosis.

research Reversal of Baldness in Patient Receiving Minoxidil for Hypertension

95 citations , December 1980 in “The New England Journal of Medicine”

Minoxidil helped bald patient regrow hair.

research Corticosteroids in the Treatment of Alopecia Totalis

28 citations , October 1978 in “Archives of dermatology”

This study found that combined topical, intralesional, and oral corticosteroids led to significant hair regrowth in some patients with alopecia totalis or universalis, allowing eventual cessation of oral corticosteroids in several cases.

research Perilymphatic Atrophy of the Skin

25 citations , June 1975 in “Archives of Dermatology”

This case report describes a 34-year-old woman who developed skin atrophy along lymphatic vessels after receiving triamcinolone acetonide injections for alopecia areata.

research Cutaneous Corticosteroid Injection and Amaurosis

34 citations , November 1974 in “Archives of Dermatology”

This report discusses historical cases of visual side effects from scalp corticosteroid injections for alopecia areata and attributes their rarity now to improved injection techniques and smaller particulate sizes in suspensions.

research Treatment of Alopecia Areata With Steroid Solution

30 citations , December 1972 in “Archives of dermatology”

This report examines efforts to enhance the efficacy of topical steroids for alopecia areata using penetration-enhancing vehicles and exceptionally high concentrations, noting systemic steroids often lead to relapses and toxicity.

research A Comparison of Intralesional Triamcinolone Hexacetonide and Triamcinolone Acetonide in Alopecia Areata

75 citations , September 1971 in “British Journal of Dermatology”

This study found that both intralesional triamcinolone acetonide and triamcinolone hexacetonide promote continuous hair growth in alopecia areata, with effects lasting at least 9 months after a single injection.

research Steroid Therapy in Alopecia Universalis

4 citations , June 1963 in “Archives of Dermatology”

This article reviews alopecia treatment and reports a case where hair regrew rapidly with prednisolone, but fell out again after stopping the medication; no new results are presented.

research Alopecia Totalis: Significant Hair Regrowth with Fluocinolone Acetonide Cream

22 citations , March 1963 in “Archives of dermatology”

This case report describes hair regrowth in a patient with alopecia totalis using fluocinolone acetonide cream applied under thin plastic films.

research Triamcinolone Suspension in Alopecia Areata

15 citations , June 1961 in “Archives of Dermatology”

This report details observations from four patients with alopecia areata who received intralesional triamcinolone injections to assess its effectiveness for promoting hair regrowth in localized areas.

research Alopecia Areata of Eyebrows—Corticosteroids

11 citations , January 1961 in “Archives of dermatology”

In this study, corticosteroid injections were found to be more effective than saline for inducing hair regrowth in cases of alopecia areata with long-duration and extensive hair loss.

research Local Injection of Steroids and Hair Regrowth in Alopecias

57 citations , December 1960 in “Archives of Dermatology”

This introduction reviews historical use of steroids for alopecia treatment, mentioning early cases of hair regrowth with cortisone acetate but provides no new clinical data.