Treatment of Alopecia Areata With Steroid Solution
December 1972
in “
Archives of dermatology
”
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Studysummary This report examines efforts to enhance the efficacy of topical steroids for alopecia areata using penetration-enhancing vehicles and exceptionally high concentrations, noting systemic steroids often lead to relapses and toxicity.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
The study investigated the efficacy of a high-strength steroid solution (2.5% dexamethasone in a penetration-enhancing vehicle) for treating alopecia areata in 32 patients. Group 1 (10 patients) applied the solution topically, resulting in hair regrowth in 6 patients, though 2 experienced recurrence after stopping treatment. Group 2 (22 patients) received an initial oral prednisone regimen followed by the topical solution, leading to hair regrowth in 18 patients, with 6 developing folliculitis. The study concluded that while the high-strength steroid solution could induce hair regrowth, it often caused folliculitis and comedo formation, and hair growth was not sustained in untreated control areas.
