Treatment of Alopecia Areata With Steroid Solution

    December 1972 in “ Archives of dermatology ”
    James J. Leyden
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    TLDR The steroid solution can regrow hair but often causes skin issues and doesn't work long-term.
    The study investigated the efficacy of a high-strength steroid solution (2.5% dexamethasone in a penetration-enhancing vehicle) for treating alopecia areata in 32 patients. Group 1 (10 patients) applied the solution topically, resulting in hair regrowth in 6 patients, though 2 experienced recurrence after stopping treatment. Group 2 (22 patients) received an initial oral prednisone regimen followed by the topical solution, leading to hair regrowth in 18 patients, with 6 developing folliculitis. The study concluded that while the high-strength steroid solution could induce hair regrowth, it often caused folliculitis and comedo formation, and hair growth was not sustained in untreated control areas.
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