TLDR Tofacitinib is effective and safe for treating alopecia areata.
The clinical trial conducted at the Department of Dermatology and Venereology, Bangabandhu Sheikh Mujib Medical University, Dhaka from July 2018 to December 2019 involved 45 patients with patchy alopecia areata, alopecia totalis, and alopecia universalis. These patients were treated with Tofacitinib, a Janus kinase inhibitor, at 5mg twice daily for 6 months. The results showed that 84.6% of patients with patchy alopecia areata, 72.7% with alopecia totalis, and 62.5% with alopecia universalis experienced full hair regrowth. However, 24.4% of the patients experienced side effects such as nausea, headache, and high respiratory tract infection. The study concluded that Tofacitinib is an effective and safe treatment for alopecia areata.
October 2022 in “Journal of Armed Forces Medical College, Bangladesh” Tofacitinib is effective and safe for treating alopecia areata.
September 2022 in “Journal of the American Academy of Dermatology” The registry showed that tofacitinib is promising for treating hair loss in children with alopecia areata, but more research is needed.
1 citations,
August 2022 in “JAAD case reports” Tofacitinib and oral minoxidil may help treat Sisaipho alopecia areata.
January 2021 in “Our Dermatology Online” Oral tofacitinib successfully treated total body hair loss in one patient.
1 citations,
October 2020 in “Journal of Cosmetic Dermatology” Using minoxidil and tofacitinib together can effectively treat severe hair loss.
23 citations,
September 2019 in “Journal of The American Academy of Dermatology” Tofacitinib and oral minoxidil together effectively regrow hair in severe alopecia areata patients.
51 citations,
June 2016 in “Journal of the European Academy of Dermatology and Venereology” Tofacitinib was effective in treating hair loss in two patients with alopecia universalis.
36 citations,
May 2011 in “Dermatologic therapy” No treatments fully cure or prevent alopecia areata; some help but have side effects or need more research.
71 citations,
March 2009 in “Seminars in cutaneous medicine and surgery” Alopecia areata can cause unpredictable hair loss, and treatments like corticosteroids and minoxidil may help but have varying side effects.
