Investigative Guidelines for Alopecia Areata

The document discussed the challenges in comparing the efficacy of various treatments for alopecia areata due to the lack of consideration for spontaneous regrowth, baseline prognostic factors, and quantification of hair growth in case reports and clinical trials. It provided guidelines for clinical trial design that accounted for variables like baseline severity, pattern, duration of hair loss, age, and concomitant conditions. The report also covered reliable methods for assessing efficacy and response criteria to enable direct comparison of results between different treatments.