Topical Nitrogen Mustard in the Treatment of Alopecia Areata: A Bilateral Comparison Study

    August 2003 in “ Journal of The American Academy of Dermatology ”
    Olga Bernardo, Lisa Tang, Harvey Lui, Jerry Shapiro
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    TLDR Nitrogen mustard was not very effective for hair regrowth in alopecia areata and has potential skin cancer risk.
    In a study from 2003, 10 patients with significant alopecia areata were treated with 0.02% topical nitrogen mustard on one half of their scalp. Only 6 patients completed the 16-week trial, and of those, just 1 patient showed significant hair regrowth, with the Hair Growth Index increasing from 10 to 150 on the treated side. One patient had a contact hypersensitivity reaction, but all participants maintained normal blood cell counts. The study suggested that mechlorethamine might have an immunomodulatory effect on T cells, but also noted the risk of skin cancer with long-term use, making it a less than ideal treatment for alopecia areata. Further research was recommended to investigate higher concentrations or longer treatment times and to better understand the treatment's mechanisms.
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      community mbp alopecia areata or vitamin deficiency

      in Chat 4 months ago
      A 19-year-old male has been using topical finasteride and minoxidil for 8 months with no progress and is considering seeking a second opinion due to potential misdiagnosis. The discussion revolves around whether the hair loss is due to male pattern baldness, alopecia areata, or a vitamin deficiency.

      community Using topical vitamin D, does it make sense?

      in Chat  6 upvotes 2 years ago
      Topical Calcipotriol (vitamin D derivative) may help with hair regrowth, especially for alopecia areata. The user wonders if adding classic vitamin D to lotions like Minoxidil could have a similar effect.

      community any news about DUPA (Diffuse unpatterned alopecia)?

      in Research/Science  11 upvotes 1 year ago
      The conversation discusses diffuse unpatterned alopecia (DUPA) and its possible causes, including sensitivity to DHT, not being androgenic alopecia, being diffuse alopecia areata, or hormonal issues. Treatments mentioned include topical melatonin, Clobetasol Propionate for alopecia areata, and the lack of results from using finasteride, dutasteride, and minoxidil.

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