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GlossaryNitrogen Mustard (Mechlorethamine)

chemotherapy drug derived from chemical warfare agents

Nitrogen Mustard, also known as Mechlorethamine, is a type of chemotherapy drug originally derived from chemical warfare agents. It works by interfering with the DNA of rapidly dividing cells, making it effective in treating certain cancers, such as Hodgkin's lymphoma. However, it can also cause side effects like hair loss (alopecia) due to its impact on healthy rapidly dividing cells, including those in hair follicles.

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Topical Mechlorethamine Restores Autoimmune-Arrested Follicular Activity in Mice with an Alopecia Areata-Like Disease by Targeting Infiltrated Lymphocytes

research Topical Mechlorethamine Restores Autoimmune-Arrested Follicular Activity in Mice with an Alopecia Areata-Like Disease by Targeting Infiltrated Lymphocytes

19 citations, March 2003 in “Journal of Investigative Dermatology”

Mechlorethamine treatment regrew hair in mice by killing immune cells causing hair loss without harming hair follicles.

research Old Wine in New Bottles: Reviving Old Therapies for Alopecia Areata Using Rodent Models

17 citations, September 2003 in “Journal of Investigative Dermatology Symposium Proceedings”

Old treatments for other skin conditions showed promise for hair regrowth in mice with a hair loss condition.

research Topical Nitrogen Mustard in the Treatment of Alopecia Areata: A Bilateral Comparison Study

16 citations, August 2003 in “Journal of The American Academy of Dermatology”

Nitrogen mustard was not very effective for hair regrowth in alopecia areata and has potential skin cancer risk.

The Possible Role of Prescribing Medications in Contributing to Male-Factor Infertility: Assessment of the FDA Pharmacovigilance Database

research The Possible Role of Prescribing Medications in Contributing to Male-Factor Infertility: Assessment of the FDA Pharmacovigilance Database

November 2023 in “Brain Sciences”

Some medications might contribute to male infertility, with finasteride showing a high number of reports.

research Cutaneous Complications of Chemotherapeutic Agents

172 citations, November 1983 in “Journal of The American Academy of Dermatology”

Chemotherapy can cause skin problems like hair loss, mouth sores, and skin darkening, and recognizing these can affect treatment decisions.

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