Topical Mechlorethamine Restores Autoimmune-Arrested Follicular Activity in Mice with an Alopecia Areata-Like Disease by Targeting Infiltrated Lymphocytes

    March 2003 in “ Journal of Investigative Dermatology ”
    Lisa Tang, Liping Cao, Olga Bernardo … Jerry Shapiro
    Studysummary This study found that mechlorethamine restored hair growth in mice with alopecia-areata-like disease by eliminating infiltrated lymphocytes and inhibiting certain pro-inflammatory cytokines in treated skin areas.
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    Research cited in this study 6

    1. Experimental Induction of Alopecia Areata-Like Hair Loss in C3H/HeJ Mice Using Full-Thickness Skin Grafts ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1998
    2. Hair Regrowth Dermatologic Clinics · 1998
    3. Transgenic Mice Expressing IFN-γ in the Epidermis Have Eczema, Hair Hypopigmentation, and Hair Loss Journal of Investigative Dermatology · 1997
    4. The Pathogenesis of Alopecia Areata Dermatologic Clinics · 1996
    5. Mouse Models for the Study of Human Hair Loss Dermatologic Clinics · 1996
    6. Alopecia Areata in Aging C3H/HeJ Mice Journal of Investigative Dermatology · 1994

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