TLDR Mechlorethamine treatment regrew hair in mice by killing immune cells causing hair loss without harming hair follicles.
In the 2003 study, 24 female C3H/HeJ mice with an induced alopecia areata-like disease were treated with topical mechlorethamine. The treatment led to full hair regrowth on the treated side of the mice after 10 weeks, while the control side showed no improvement. The study demonstrated that mechlorethamine effectively eliminated CD4 and CD8+ lymphocytes from the skin, which are key in the disease's progression, and was more cytotoxic to lymphocytes than to skin and follicular cells. Additionally, mechlorethamine reduced the production of inflammatory cytokines such as TNF-α/β, IL-12, and IFN-γ. These results suggest that mechlorethamine can selectively target the immune cells responsible for hair loss in alopecia areata without damaging hair follicles and may offer a potential treatment for the condition by inhibiting inflammatory cytokines.
Cited in this study
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131 citations
,
November 1998 in “The journal of investigative dermatology/Journal of investigative dermatology” Skin grafts on mice can cause an immune response leading to hair loss, useful for studying human hair loss conditions.
118 citations
,
April 1998 in “Dermatologic Clinics” Finasteride and minoxidil are effective for hair regrowth, while treatments for alopecia areata have varying success and continuous treatment is necessary.
89 citations
,
October 1996 in “Dermatologic Clinics” Alopecia areata is likely caused by a combination of genetic factors and immune system dysfunction, and may represent different diseases with various causes.
36 citations
,
October 1996 in “Dermatologic Clinics” Mice are useful for researching human hair loss and testing treatments, despite some differences between species.
4 citations
,
May 2020 in “JAAD case reports” JAK inhibitors help hair regrowth but not fully effective for androgenetic alopecia.
August 2018 in “Oxford University Press eBooks” The document's conclusion cannot be provided because the document cannot be parsed.
32 citations
,
December 2017 in “International Journal of Molecular Sciences” Low vitamin D might be linked to certain types of hair loss, and supplements could help, but more research is needed.
January 2011 Loss of oil glands and inflammation might contribute to the development of scarring hair loss.
29 citations
,
October 2008 in “Journal of Cutaneous Pathology” Hair root sheaths are more common in non-scarring hair loss and help diagnose the type of hair loss.
5 citations
,
October 1988 in “Clinics in Dermatology” Minoxidil promotes hair growth but exact mechanism is unknown.
