Topical Ruxolitinib for the Treatment of Alopecia Universalis

December 2015 in “ JAMA dermatology ”

Brittany G. Craiglow, Daniel Tavares, Brett King

topical Ruxolitinib Alopecia Universalis alopecia areata Janus kinase inhibitors JAK inhibitors

TLDR Topical Ruxolitinib may safely treat severe hair loss.

The document discussed the potential of topical Ruxolitinib as a treatment for Alopecia Universalis, a severe form of alopecia areata. While oral Janus kinase (JAK) inhibitors had been effective in treating these conditions, they carried risks of serious adverse effects. The study suggested that using a topical form of Ruxolitinib could mitigate these risks, offering a safer alternative for patients.

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Research cited in this study

2 / 2 results

research Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition

701 citations, August 2014 in “Nature medicine”

Alopecia areata can be reversed by JAK inhibitors, promoting hair regrowth.

research Killing Two Birds with One Stone: Oral Tofacitinib Reverses Alopecia Universalis in a Patient with Plaque Psoriasis

185 citations, June 2014 in “Journal of Investigative Dermatology”

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