Topical Ruxolitinib for the Treatment of Alopecia Universalis

December 2015 in “ JAMA dermatology ”

Brittany G. Craiglow, Daniel Tavares, Brett King

topical Ruxolitinib Alopecia Universalis alopecia areata Janus kinase inhibitors JAK inhibitors

TLDR Topical Ruxolitinib may safely treat severe hair loss.

The document discussed the potential of topical Ruxolitinib as a treatment for Alopecia Universalis, a severe form of alopecia areata. While oral Janus kinase (JAK) inhibitors had been effective in treating these conditions, they carried risks of serious adverse effects. The study suggested that using a topical form of Ruxolitinib could mitigate these risks, offering a safer alternative for patients.

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Research cited in this study

2 / 2 results

research Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition

701 citations, August 2014 in “Nature medicine”

Alopecia areata can be reversed by JAK inhibitors, promoting hair regrowth.

research Killing Two Birds with One Stone: Oral Tofacitinib Reverses Alopecia Universalis in a Patient with Plaque Psoriasis

185 citations, June 2014 in “Journal of Investigative Dermatology”

A man with severe hair loss and skin disease regrew his hair with no side effects after taking tofacitinib.

Related Community Posts Join

6 / 1000+ results

community What else is good. Besides the big 3.

in Chat 35 upvotes 10 months ago

Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

community Ruxolitinib - Start of a case study

in Research/Science 10 upvotes 1 year ago

The conversation is about a user trying a new hair loss treatment, Ruxolitinib, alongside their existing regimen of finasteride, minoxidil, ketoconazole shampoo, and microneedling. They plan to apply Ruxolitinib to their temples daily for 1-2 months.

community Topical Minoxidil 5% since March but does seem to be improving much.

in Progress Pictures 178 upvotes 1 day ago

Minoxidil 5% alone is not enough for significant hair regrowth; combining it with finasteride or dutasteride is advised. A hair transplant might be needed, depending on baldness extent and donor area quality.

community topical minoxidil, botana oil, coconut moisturizer, derma stamping, derma rolling, 3% salicylic acid shampoo, and scalp massage results thus far

in Progress Pictures 4 upvotes 5 days ago

The user shares their hair loss treatment routine, which includes topical minoxidil, botana oil, coconut moisturizer, derma stamping, derma rolling, 3% salicylic acid shampoo, and scalp massage. Suggestions include adding finasteride, switching to 2% ketoconazole shampoo, and using rosemary oil instead of botana oil.

community topical DUT with dermapen, which form to order?

in Finasteride/Dutasteride 6 days ago

The conversation discusses using topical dutasteride with a dermapen for hair loss treatment. The user is deciding between liposomal and mesosomal formulations for this purpose.

community Is Topical Finasteride Safe for Cats in My Home?

in Finasteride 46 upvotes 2 weeks ago

Topical finasteride is not known to be toxic to cats like minoxidil, but careful handling is advised to prevent ingestion or skin contact. OP seeks reassurance to convince their girlfriend of its safety around their cat.

Related Research

3 / 3 results

research Alopecia Universalis Treated With Tofacitinib: The Role of JAK/STAT Inhibitors in Hair Regrowth

November 2023 in “Cutis”

Tofacitinib helped a woman with total-body hair loss grow her hair back.

Tofacitinib (Selective Janus Kinase Inhibitor 1 and 3): A Promising Therapy for the Treatment of Alopecia Areata: A Case Report of Six Patients

research Tofacitinib (Selective Janus Kinase Inhibitor 1 and 3): A Promising Therapy for the Treatment of Alopecia Areata: A Case Report of Six Patients

24 citations, January 2018 in “International Journal of Trichology”

Tofacitinib helped regrow hair in patients with alopecia, with few side effects.

research Excellent Response to Tofacitinib Treatment in a Patient with Alopecia Universalis

16 citations, January 2017 in “Acta dermatovenerologica Alpina, Pannonica et Adriatica (Tiskana izd.)”

A patient with complete hair loss regrew all her hair using tofacitinib.