Topical Ruxolitinib for the Treatment of Alopecia Universalis

December 2015 in “ JAMA dermatology ”

Brittany G. Craiglow, Daniel Tavares, Brett King

topical Ruxolitinib Alopecia Universalis alopecia areata Janus kinase inhibitors JAK inhibitors

TLDR Topical Ruxolitinib may safely treat severe hair loss.

The document discussed the potential of topical Ruxolitinib as a treatment for Alopecia Universalis, a severe form of alopecia areata. While oral Janus kinase (JAK) inhibitors had been effective in treating these conditions, they carried risks of serious adverse effects. The study suggested that using a topical form of Ruxolitinib could mitigate these risks, offering a safer alternative for patients.

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Research cited in this study

2 / 2 results

research Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition

701 citations, August 2014 in “Nature medicine”

Alopecia areata can be reversed by JAK inhibitors, promoting hair regrowth.

research Killing Two Birds with One Stone: Oral Tofacitinib Reverses Alopecia Universalis in a Patient with Plaque Psoriasis

185 citations, June 2014 in “Journal of Investigative Dermatology”

A man with severe hair loss and skin disease regrew his hair with no side effects after taking tofacitinib.

Related Community Posts Join

6 / 1000+ results

community What else is good. Besides the big 3.

in Chat 34 upvotes 3 months ago

Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

community Ruxolitinib - Start of a case study

in Research/Science 10 upvotes 8 months ago

The conversation is about a user trying a new hair loss treatment, Ruxolitinib, alongside their existing regimen of finasteride, minoxidil, ketoconazole shampoo, and microneedling. They plan to apply Ruxolitinib to their temples daily for 1-2 months.

community How come topical fin doesn't deliver superior results when it suppresses scalp DHT more effectively than oral?

in Finasteride/Dutasteride 38 upvotes 5 days ago

Topical finasteride is believed to reduce scalp DHT more than oral forms, but its effectiveness is questioned due to inconsistent application and absorption. Oral finasteride is considered more effective because it consistently reduces systemic DHT, ensuring more reliable results.

community Is there any role for topical DHT antagonists, or does a 5-AR inhibitor remove the need for them as therapy

in Research/Science 2 upvotes 2 weeks ago

Topical androgen receptor antagonists may not be necessary if 5-AR inhibitors like finasteride or dutasteride effectively reduce DHT levels. Combining a 5-AR inhibitor with a topical androgen antagonist could potentially enhance treatment, but oral use of androgen antagonists is too risky due to severe side effects.

community topical Minoxidil - Ru58841 makes my hair look and feel really brittle and thin

in Minoxidil 1 upvotes 3 weeks ago

Topical Minoxidil and RU58841 can make hair look brittle and thin, possibly due to the propylene glycol in their solutions. Some users experience side effects like heart palpitations with RU58841, while others have no issues.

community Haircafe - TOPICAL minoxidil is an anti aging drug

in Minoxidil 245 upvotes 4 weeks ago

Topical minoxidil may cause skin aging effects like wrinkles and dark circles, possibly due to its alcohol content, while oral finasteride is reported to make users look younger. Switching to oral minoxidil or using moisturizers might help reduce these skin issues.

Related Research

3 / 3 results

research Alopecia Universalis Treated With Tofacitinib: The Role of JAK/STAT Inhibitors in Hair Regrowth

November 2023 in “Cutis”

Tofacitinib helped a woman with total-body hair loss grow her hair back.

Tofacitinib (Selective Janus Kinase Inhibitor 1 and 3): A Promising Therapy for the Treatment of Alopecia Areata: A Case Report of Six Patients

research Tofacitinib (Selective Janus Kinase Inhibitor 1 and 3): A Promising Therapy for the Treatment of Alopecia Areata: A Case Report of Six Patients

24 citations, January 2018 in “International Journal of Trichology”

Tofacitinib helped regrow hair in patients with alopecia, with few side effects.

research Excellent Response to Tofacitinib Treatment in a Patient with Alopecia Universalis

16 citations, January 2017 in “Acta dermatovenerologica Alpina, Pannonica et Adriatica (Tiskana izd.)”

A patient with complete hair loss regrew all her hair using tofacitinib.