L-Ascorbic Acid 2-Phosphate Promotes Elongation of Hair Shafts via the Secretion of Insulin-Like Growth Factor-1 from Dermal Papilla Cells Through Phosphatidylinositol 3-Kinase

    March 2009 in “ British journal of dermatology/British journal of dermatology, Supplement ”
    Mi Hee Kwack, Sug Kyun Shin, S.R. Kim … Young Kwan Sung
    Studysummary In this study, l-Ascorbic acid 2-phosphate was found to stimulate hair follicle growth in vitro by promoting IGF-1 expression via the PI3K pathway.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on academic.oup.com →
    Discuss this study in the Community →

    Research cited in this study 10

    1. Effect of Topical Application of Raspberry Ketone on Dermal Production of Insulin-Like Growth Factor-I in Mice and on Hair Growth and Skin Elasticity in Humans Growth hormone & IGF research · 2008
    2. Transcriptional Activation of CCN1 and CCN2, Targets of Canonical Wnt Signal, by Ascorbic Acid 2-Phosphate in Human Dermal Papilla Cells Journal of Dermatological Science · 2007
    3. Induction of Versican by Ascorbic Acid 2-Phosphate in Dermal Papilla Cells Journal of Dermatological Science · 2006
    4. The Hair Growth Promoting Effect of Ascorbic Acid 2-Phosphate, a Long-Acting Vitamin C Derivative Journal of Dermatological Science · 2006
    5. The Expression of Insulin-Like Growth Factor 1 in Follicular Dermal Papillae Correlates with Therapeutic Efficacy of Finasteride in Androgenetic Alopecia Journal of The American Academy of Dermatology · 2003
    6. Molecular Control of Epithelial-Mesenchymal Interactions During Hair Follicle Cycling ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings · 2003
    7. Simple and Rapid Method to Isolate and Culture Follicular Papillae from Human Scalp Hair Follicles Experimental Dermatology · 2002
    8. Insulin-Like Growth Factor 1 and Hair Growth Dermatology Online Journal · 1999
    9. Overexpression of Insulin-Like Growth Factor-1 Induces Hyperplasia, Dermal Abnormalities, and Spontaneous Tumor Formation in Transgenic Mice Oncogene · 1997
    10. Androgen Induction of Follicular Epithelial Cell Growth Is Mediated via Insulin-like Growth Factor-I from Dermal Papilla Cells Biochemical and biophysical research communications · 1995

    Related research 7

    1. Possible Cellular Communication with Human Follicle Dermal Papilla Cells via Secretions from Human Hair Follicle Keratinocytes Journal of St. Marianna University · 2022
    2. A Model System to Analyze the Ability of Human Keratinocytes to Form Hair Follicles Experimental Dermatology · 2014
    3. Review of Hair Follicle Dermal Cells Journal of Dermatological Science · 2009
    4. Hair Follicle Reformation Induced by Dermal Papilla Cells from Human Scalp Skin Archives of Dermatological Research · 2006
    5. Study on Hair Follicle Formation Induced by Dermal Papilla Cells Chinese Journal of Reparative and Reconstructive Surgery · 2003
    6. Trans-Species Hair Growth Induction by Human Hair Follicle Dermal Papillae Experimental Dermatology · 2001
    7. Role of Hair Papilla Cells in Induction and Regeneration Processes of Hair Follicles Wound Repair and Regeneration · 1998