Transcriptional Activation of CCN1 and CCN2, Targets of Canonical Wnt Signal, by Ascorbic Acid 2-Phosphate in Human Dermal Papilla Cells

In a 2008 study, researchers discovered that L-ascorbic acid 2-phosphate magnesium salt (Asc 2-P), a Vitamin C derivative, promotes the nuclear accumulation of β-catenin and upregulates the expression of CCN1/Cyr61 and CCN2/CTGF in human dermal papilla cells. These genes are part of the Wnt/β-catenin pathway, which is crucial for hair follicle development and cycling. The findings indicate that Asc 2-P could potentially affect hair growth and cycling by influencing this pathway. The study was conducted on primary cultured cells from human hair follicles, but the exact number of samples was not mentioned.