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GlossaryAscorbyl-2-Phosphate (Asc 2-P)

stable, water-soluble Vitamin C derivative used in skincare

Ascorbyl-2-Phosphate (Asc 2-P) is a stable, water-soluble derivative of Vitamin C. It is commonly used in skincare and hair care products due to its antioxidant properties, which help protect cells from damage, promote collagen synthesis, and improve skin and hair health.

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research L-Ascorbic Acid 2-Phosphate Promotes Elongation of Hair Shafts via the Secretion of Insulin-Like Growth Factor-1 from Dermal Papilla Cells Through Phosphatidylinositol 3-Kinase

34 citations, June 2009 in “British journal of dermatology/British journal of dermatology, Supplement”

Vitamin C derivative helps hair grow longer by making cells produce a growth factor through a specific cellular pathway.

research The Hair Growth Promoting Effect of Ascorbic Acid 2-Phosphate, a Long-Acting Vitamin C Derivative

33 citations, January 2006 in “Journal of Dermatological Science”

A long-acting Vitamin C derivative helps hair grow by stimulating cells and increasing growth factors.

research Induction of Versican by Ascorbic Acid 2-Phosphate in Dermal Papilla Cells

22 citations, April 2006 in “Journal of Dermatological Science”

Vitamin C derivative increases versican in cells, potentially aiding hair growth.

Transcriptional Activation of CCN1 and CCN2, Targets of Canonical Wnt Signal, by Ascorbic Acid 2-Phosphate in Human Dermal Papilla Cells

research Transcriptional Activation of CCN1 and CCN2, Targets of Canonical Wnt Signal, by Ascorbic Acid 2-Phosphate in Human Dermal Papilla Cells

14 citations, November 2007 in “Journal of Dermatological Science”

Vitamin C derivative may promote hair growth by activating specific genes.

research L-Ascorbic Acid 2-Phosphate Represses Dihydrotestosterone-Induced Dickkopf-1 Expression in Human Balding Dermal Papilla Cells

13 citations, November 2010 in “Experimental Dermatology”

Vitamin C derivative reduces hair loss-related protein in cells.

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community Why is Minoxidil not enough for hair loss? (No fin)

in Minoxidil 57 upvotes 6 days ago

Minoxidil alone is often insufficient for treating hair loss because it doesn't address the DHT-related cause. Combining it with finasteride, a DHT blocker, is generally more effective.

community ASC-J9: Poor man’s GT-20029 that might work for regrowth. Anyone try this stuff?

in Research/Science 1 year ago

The potential hair regrowth benefits of ASC-J9, a synthetic modified version of curcumin that is said to be more effective than Minoxidil and Finasteride. Reports from users suggest good thickening and temple regrowth with topical use at 0.025% concentration.

community Anyone else just waiting until the real pyrilutamide and then GT20029?

in Chat 1 year ago

The user is hesitant to use finasteride due to potential hormonal side effects and is waiting for the release of pyrilutamide, a new hair loss treatment. Other users suggest trying finasteride, warning about potential regret if hair loss progresses in the meantime.

community Peptides that Stop Hair Loss? | In-depth Literature Review Video

in Research/Science 74 upvotes 5 months ago

Peptides like TB500, KPV, GHK-CU, and BPC-157 are overhyped for hair growth with limited proven effectiveness in humans. Combining peptides with delivery methods like iontophoresis and sonophoresis shows promise, but many claims remain unproven.

community Is ketoconazole very effective?

in Ketoconazole 10 upvotes 6 months ago

A user is considering using ketoconazole shampoo for hair loss and is seeking feedback on its effectiveness. They are asking for before and after photos or success stories.