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GlossaryPhosphoinositide 3-kinase

enzyme involved in cell growth and survival signaling

Phosphoinositide 3-kinase (PI3K) is an enzyme that plays a crucial role in cell growth, proliferation, and survival by activating signaling pathways inside cells. It is particularly important in the context of cancer research, as abnormal PI3K activity can lead to uncontrolled cell division and tumor growth.

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research L-Ascorbic Acid 2-Phosphate Promotes Elongation of Hair Shafts via the Secretion of Insulin-Like Growth Factor-1 from Dermal Papilla Cells Through Phosphatidylinositol 3-Kinase

34 citations, June 2009 in “British journal of dermatology/British journal of dermatology, Supplement”

Vitamin C derivative helps hair grow longer by making cells produce a growth factor through a specific cellular pathway.

research Phosphatidylinositol 3-Kinase/Akt-Dependent and Independent Protection Against Apoptosis in Normal Human Melanocytes

16 citations, October 2004 in “Journal of Investigative Dermatology”

Normal human melanocytes can avoid cell death through multiple pathways.

Retinoid-Mediated Stimulation of Steroid Sulfatase Activity in Myeloid Leukemic Cell Lines Requires RARα and RXR and Involves the Phosphoinositide 3-Kinase and ERK-MAP Kinase Pathways

research Retinoid-Mediated Stimulation of Steroid Sulfatase Activity in Myeloid Leukemic Cell Lines Requires RARα and RXR and Involves the Phosphoinositide 3-Kinase and ERK-MAP Kinase Pathways

24 citations, September 2005 in “Journal of Cellular Biochemistry”

Retinoids increase steroid sulfatase activity in leukemia cells through RARα/RXR and involves certain pathways like phosphoinositide 3-kinase and ERK-MAP kinase.

research Induction of Versican by Ascorbic Acid 2-Phosphate in Dermal Papilla Cells

22 citations, April 2006 in “Journal of Dermatological Science”

Vitamin C derivative increases versican in cells, potentially aiding hair growth.

research Managing Hyperglycemia and Rash Associated With Alpelisib: Expert Consensus Recommendations Using the Delphi Technique

1 citations, January 2024 in “NPJ breast cancer”

Experts agree on how to manage sugar levels and skin reactions in patients taking the cancer drug alpelisib.

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