Ginsenoside Rb1 Promotes the Growth of Mink Hair Follicle via PI3K/AKT/GSK-3β Signaling Pathway

May 2019 in “ Life Sciences ”

Haihua Zhang, Yongmei Su, Jiantao Wang, Ying Gao, Fenghuan Yang, Guangyu Li, Qiumei Shi

ginsenoside Rb1 Panax ginseng hair follicle growth dermal papilla cells PI3K/AKT/GSK-3β signaling pathway VEGFA VEGF-R2 TGF-ß1 ginseng

TLDR Ginsenoside Rb1 from Panax ginseng helps mink hair grow by activating certain cell signals.

The study demonstrated that ginsenoside Rb1, a compound from Panax ginseng, significantly promotes mink hair follicle growth and enhances the proliferation and migration of dermal papilla cells (DPCs). This effect is mediated through the activation of the PI3K/AKT/GSK-3β signaling pathway, as evidenced by increased expression of VEGFA and its receptor VEGF-R2, and decreased expression of TGF-ß1. The study, which used 15 hair follicles per group and cultured DPCs with ginsenoside Rb1 for 96 hours, supports the potential therapeutic use of ginsenoside Rb1 in hair growth promotion.

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