Ginsenoside Rb1 Promotes the Growth of Mink Hair Follicle via PI3K/AKT/GSK-3β Signaling Pathway

May 2019 in “ Life Sciences ”

Haihua Zhang, Yongmei Su, Jiantao Wang, Ying Gao, Fenghuan Yang, Guangyu Li, Qiumei Shi

ginsenoside Rb1 Panax ginseng hair follicle growth dermal papilla cells PI3K/AKT/GSK-3β signaling pathway VEGFA VEGF-R2 TGF-ß1 ginseng

TLDR Ginsenoside Rb1 from Panax ginseng helps mink hair grow by activating certain cell signals.

The study demonstrated that ginsenoside Rb1, a compound from Panax ginseng, significantly promotes mink hair follicle growth and enhances the proliferation and migration of dermal papilla cells (DPCs). This effect is mediated through the activation of the PI3K/AKT/GSK-3β signaling pathway, as evidenced by increased expression of VEGFA and its receptor VEGF-R2, and decreased expression of TGF-ß1. The study, which used 15 hair follicles per group and cultured DPCs with ginsenoside Rb1 for 96 hours, supports the potential therapeutic use of ginsenoside Rb1 in hair growth promotion.

View this study on sciencedirect.com →

Discuss this study in the Community →

Research cited in this study

18 / 18 results

research Mackerel-Derived Fermented Fish Oil Promotes Hair Growth by Anagen-Stimulating Pathways

14 citations, September 2018 in “International Journal of Molecular Sciences”

Mackerel-derived fermented fish oil helps hair grow by activating growth pathways and increasing cell proliferation.

research Effect of Sinapic Acid on Hair Growth Promotion in Human Hair Follicle Dermal Papilla Cells via Akt Activation

25 citations, March 2017 in “Archives of Dermatological Research”

Sinapic acid may help hair growth by activating a specific cell pathway.

research Hair Growth-Promoting Effect of Geranium Sibiricum Extract in Human Dermal Papilla Cells and C57BL/6 Mice

36 citations, February 2017 in “BMC Complementary and Alternative Medicine”

Geranium sibiricum extract helps hair grow and is more effective than minoxidil but can be toxic in high concentrations.

research Hair Follicle Stem Cell Proliferation, Akt and Wnt Signaling Activation in TPA-Induced Hair Regeneration

30 citations, February 2017 in “Histochemistry and Cell Biology”

TPA promotes hair growth by increasing stem cell activity and activating specific cell signals.

Surface Tension Guided Hanging-Drop: Producing Controllable 3D Spheroids of High-Passaged Human Dermal Papilla Cells and Forming Inductive Microtissues for Hair-Follicle Regeneration

research Surface Tension Guided Hanging-Drop: Producing Controllable 3D Spheroids of High-Passaged Human Dermal Papilla Cells and Forming Inductive Microtissues for Hair-Follicle Regeneration

62 citations, February 2016 in “ACS Applied Materials & Interfaces”

Technique creates 3D cell spheroids for hair-follicle regeneration.

research Human Placental Extract Exerts Hair Growth-Promoting Effects Through the GSK-3β Signaling Pathway in Human Dermal Papilla Cells

20 citations, August 2015 in “International Journal of Molecular Medicine”

Human placental extract may help hair growth by affecting certain cell signals and could be more effective with minoxidil.

research The Ginsenosides of Panax Ginseng Promote Hair Growth via Similar Mechanism of Minoxidil

21 citations, January 2015 in “Journal of Dermatological Science”

Ginsenosides in Panax ginseng boost hair growth like minoxidil.

research Herbal Extracts Induce Dermal Papilla Cell Proliferation of Human Hair Follicles

24 citations, January 2015 in “Annals of Dermatology”

Herbal extracts may help hair grow and could be an alternative to synthetic hair loss treatments.

research Red Ginseng Extract Promotes Hair Growth in Cultured Human Hair Follicles

49 citations, November 2014 in “Journal of Medicinal Food”

Red Ginseng Extract may help human hair grow by activating growth pathways and blocking negative effects of certain hormones.

research Exogenous IGF-1 Promotes Hair Growth by Stimulating Cell Proliferation and Downregulating TGF-β1 in C57BL/6 Mice In Vivo

53 citations, March 2014 in “Growth Hormone & IGF Research”

IGF-1 injections help mice grow more hair by increasing cell growth and blocking a hair growth inhibitor.

research Ginsenoside Rg3 Up-Regulates the Expression of Vascular Endothelial Growth Factor in Human Dermal Papilla Cells and Mouse Hair Follicles

20 citations, December 2013 in “PTR. Phytotherapy research/Phytotherapy research”

Ginsenoside Rg3 may help hair growth by increasing a growth-related protein in hair cells.

research Ginsenosides Rb1 and Rd Regulate Proliferation of Mature Keratinocytes Through Induction of p63 Expression in Hair Follicles

15 citations, September 2012 in “PTR. Phytotherapy research/Phytotherapy research”

Ginsenosides Rb₁ and Rd may help prevent hair loss by promoting hair cell growth.

research Minoxidil Activates β-Catenin Pathway in Human Dermal Papilla Cells: A Possible Explanation for Its Anagen Prolongation Effect

88 citations, February 2011 in “Journal of Dermatological Science”

Minoxidil helps hair growth by activating the β-catenin pathway.

research Nuclear Factor I-C Regulates TGF-β-dependent Hair Follicle Cycling

25 citations, August 2010 in “Journal of Biological Chemistry”

Nuclear Factor I-C is important for controlling hair growth by affecting the TGF-β1 pathway.

research L-Ascorbic Acid 2-Phosphate Promotes Elongation of Hair Shafts via the Secretion of Insulin-Like Growth Factor-1 from Dermal Papilla Cells Through Phosphatidylinositol 3-Kinase

34 citations, June 2009 in “British journal of dermatology/British journal of dermatology, Supplement”

Vitamin C derivative helps hair grow longer by making cells produce a growth factor through a specific cellular pathway.

research A Cell-Based System for Screening Hair Growth-Promoting Agents

39 citations, March 2009 in “Archives of Dermatological Research”

Apigenin may help promote hair growth and could treat hair loss.

research Effect of Minoxidil on Proliferation and Apoptosis in Dermal Papilla Cells of Human Hair Follicle

149 citations, April 2004 in “Journal of Dermatological Science”

Minoxidil boosts hair growth by increasing cell production and survival.

research Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis

520 citations, February 2001 in “Journal of Clinical Investigation”

VEGF helps hair grow and determines follicle size by increasing blood vessel growth.

Related Research

6 / 6 results

research Possible Cellular Communication with Human Follicle Dermal Papilla Cells via Secretions from Human Hair Follicle Keratinocytes

January 2022 in “Journal of St. Marianna University”

Substances from human hair cells can affect hair loss-related genes, potentially leading to new treatments for baldness.

research A Model System to Analyze the Ability of Human Keratinocytes to Form Hair Follicles

15 citations, April 2014 in “Experimental Dermatology”

Scientists developed a system to study human hair growth using skin cells, which could help understand hair development and improve skin substitutes for medical use.

research Review of Hair Follicle Dermal Cells

321 citations, December 2009 in “Journal of Dermatological Science”

Dermal cells are key in controlling hair growth and could potentially be used in hair loss treatments, but more research is needed to improve hair regeneration methods.