TLDR IGF-1 injections help mice grow more hair by increasing cell growth and blocking a hair growth inhibitor.
The document describes a study where local injections of Insulin-like growth factor 1 (IGF-1) were administered to male C57BL/6 mice, with ten mice in each experimental group. The study demonstrated that IGF-1 increased the number of hair follicles and extended the anagen phase of the hair cycle. It was observed that IGF-1 stimulated cell proliferation within the hair follicle matrix and downregulated Transforming Growth Factor Beta 1 (TGF-β1), which is known to negatively regulate hair growth. These results indicate that IGF-1 could be a potential treatment for hair loss, as it promotes hair growth by enhancing cell proliferation and inhibiting TGF-β1. The research was funded by the National Natural Science Foundation of China under grant number 31070451.
15 citations,
September 2012 in “PTR. Phytotherapy research/Phytotherapy research” Ginsenosides Rb₁ and Rd may help prevent hair loss by promoting hair cell growth.
86 citations,
May 2002 in “Journal of comparative neurology” Nerve growth in mouse skin and hair follicles happens in stages and is closely linked to hair development.
33 citations,
February 1999 in “The journal of investigative dermatology/Journal of investigative dermatology” IGF-1 increases whisker growth in transgenic mice.
100 citations,
November 1996 in “Molecular Medicine Today” Growth factors and cytokines are important for hair growth and could potentially treat hair loss, but more research is needed to overcome challenges before they can be used in treatments.
521 citations,
January 1954 in “Physiological Reviews” Hair growth is cyclic and influenced mainly by local factors.
66 citations,
July 2015 in “Journal of Molecular Biology” The document concludes that for hair and feather growth, it's better to target the environment around stem cells than the cells themselves.
Integrin alphavbeta6 is important for wound healing and hair growth, and blocking it may improve these processes.
13 citations,
January 2010 in “Advances in Biochemical Engineering / Biotechnology” Understanding hair biology is key to developing better treatments for hair and scalp issues.
5 citations,
January 2009 in “Dermato-endocrinology” ADAM 10 and ADAM 12 proteins are involved in different stages of hair growth and could be targets for treating hair disorders.
98 citations,
February 2007 in “Seminars in Cell & Developmental Biology” Androgens can both stimulate and cause hair loss, and understanding their effects is key to treating hair disorders.
2 citations,
July 2023 in “International Journal of Molecular Sciences” BFNB could be a promising treatment for hair growth.
