Ginsenosides Rb1 and Rd Regulate Proliferation of Mature Keratinocytes Through Induction of p63 Expression in Hair Follicles

The study investigated the effects of ginsenosides Rb1 and Rd on hair growth by applying them to the shaved skin of B57CL/6 mice and monitoring for 35 days. The results showed that these ginsenosides increased cell proliferation in both the anagen and telogen phases of hair follicles but did not significantly affect cell survival in the bulge and upper follicle regions. The up-regulation of p63 expression in the matrix and outer root sheath was identified as a potential mechanism for this increased proliferation. The findings suggested that ginsenosides Rb1 and Rd could be developed as therapeutic agents for preventing hair loss.