Hair Follicle Stem Cell Proliferation, Akt and Wnt Signaling Activation in TPA-Induced Hair Regeneration

February 2017 in “ Histochemistry and Cell Biology ”

Weiming Qiu, Mingxing Lei, Ling Zhou, Xiufeng Bai, Xiangdong Lai, Yu Yu, Tian Yang, Xiaohua Lian

TPA 12-o-tetradecanoylphorbol-13-acetate hair follicle stem cell proliferation Akt signaling Wnt signaling anagen phase CD34-positive hair follicle stem cells DKK1 Wnt signaling inhibitor Wnt/ß-catenin signaling pathways hair growth phase stem cell proliferation Akt pathway Wnt pathway stem cells Wnt inhibitor

TLDR TPA promotes hair growth by increasing stem cell activity and activating specific cell signals.

The study explored how TPA (12-o-tetradecanoylphorbol-13-acetate) affects hair follicle stem cell proliferation and the activation of signaling pathways during hair regeneration. It was conducted on 2-month-old C57BL/6 female mice, and the results showed that TPA application caused hair follicles to prematurely enter the growth phase (anagen) and increased the proliferation of CD34-positive hair follicle stem cells. The study revealed that TPA treatment activated Akt signaling within the hair follicle and also triggered Wnt signaling following stem cell proliferation. The importance of Wnt signaling in this process was highlighted by the fact that overexpression of DKK1, a Wnt signaling inhibitor, stopped the TPA-induced reentry of hair follicles into the anagen phase. This suggests that both Akt and Wnt/ß-catenin signaling pathways play a role in TPA-induced hair follicle regeneration.

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Research cited in this study

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