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    Glossary 12-O-Tetradecanoylphorbol-13-acetate

    chemical compound used to activate protein kinase C (PKC)

    12-O-Tetradecanoylphorbol-13-acetate, commonly known as TPA, is a chemical compound used in biological research to activate protein kinase C (PKC). It is often employed in studies related to cell differentiation, proliferation, and apoptosis, making it a valuable tool for understanding various cellular processes and diseases, including cancer and skin conditions.

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    1. Protein kinase Cepsilon is linked to 12-O-tetradecanoylphorbol-13-acetate-induced tumor necrosis factor-alpha ectodomain shedding and the development of metastatic squamous cell carcinoma in protein kinase Cepsilon transgenic mice. PubMed · 2003 · 79 citations
    2. 12-O-Tetradecanoylphorbol-13-acetate Induces Apoptosis in Renal Epithelial Cells through a Growth Signal Conflict Which Is Prevented by Activated ras1 Archives of Biochemistry and Biophysics · 2001 · 4 citations
    3. Supplemental figure 2 from Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate 2023
    4. Supplemental figure 2 from Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate 2023
    5. Induction of dark keratinocytes by 12-O-tetradecanoyl-phorbol-13-acetate and mezerein as an indicator of tumor-promoting efficiency Carcinogenesis · 1980 · 77 citations
    6. Heterogeneity of ornithine decarboxylase expression in 12-<i>O</i>-tetradecanoylphorbol-13-acetate-treated mouse skin and in epidermal tumors Carcinogenesis · 1986 · 37 citations
    7. Induction of ornithine decarboxylase in specific subpopulations of murine epidermal cells following multiple exposures to 12-<i>O</i>-tetradecanoylphorbol-13-acetate, mezerein and ethyl phenylpropriolate Carcinogenesis · 1992 · 26 citations
    8. Alterations in the expression of specific epidermal keratin markers in the hairless mouse by the topical application of the tumor promoters 2,3,7,8-tetrachlorodibenzo-<i>p</i>-dioxin and the phorbol ester 12-<i>O</i>-tetradecanoylphorbol-13-acetate Carcinogenesis · 1987 · 12 citations
    9. Overexpression of insulin-like growth factor-1 induces hyperplasia, dermal abnormalities, and spontaneous tumor formation in transgenic mice Oncogene · 1997 · 147 citations
    10. Targeted expression of spermidine/spermine N1-acetyltransferase increases susceptibility to chemically induced skin carcinogenesis Carcinogenesis · 2002 · 54 citations
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