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GlossaryInterleukin-12

protein that activates immune cells to fight infections

Interleukin-12 (IL-12) is a protein produced by certain immune cells that plays a crucial role in regulating the body's immune response. It helps activate natural killer (NK) cells and T cells, which are essential for fighting infections and cancer. IL-12 is also involved in the inflammatory response and can influence the development of autoimmune diseases.

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27 Preclinical ex vivo and in vivo evidence supporting selective inhibition of tyrosine kinase 2-dependent, IL-12-mediated signaling as a novel pharmacological strategy for alopecia areata management

research 27 Preclinical ex vivo and in vivo evidence supporting selective inhibition of tyrosine kinase 2-dependent, IL-12-mediated signaling as a novel pharmacological strategy for alopecia areata management

November 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

Blocking TYK2 might be a new way to treat hair loss from alopecia areata.

research Pathogenetic Characteristics of Mesenchymal Stem Cells in Hidradenitis Suppurativa

19 citations , October 2018 in “JAMA dermatology”

Mesenchymal stem cells in people with Hidradenitis Suppurativa are more inflammatory, possibly contributing to the disease.

Possible advantage of imiquimod and diphenylcyclopropenone combined treatment versus diphenylcyclopropenone alone: An observational study of nonresponder patients with alopecia areata

research Possible advantage of imiquimod and diphenylcyclopropenone combined treatment versus diphenylcyclopropenone alone: An observational study of nonresponder patients with alopecia areata

9 citations , April 2016 in “Australasian journal of dermatology”

Combining imiquimod with diphenylcyclopropenone may improve treatment outcomes for alopecia areata patients who don't respond to diphenylcyclopropenone alone.

research Skin Care Properties of Grape Seed Polyphenols, a By-Product of the Winery Industry

October 2012 in “Humana Press eBooks”

Grape seed extract is good for skin care, with antioxidant, anti-inflammatory, and anti-cancer effects.

research Hypoxia enhances the hair growth-promoting effects of embryonic stem cell-derived mesenchymal stem cells via NADPH oxidase 4

March 2023 in “Biomedicine & Pharmacotherapy”

Low oxygen conditions improve how well certain stem cells from embryos can make hair grow longer and faster.

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community UPDATE: The theory that explains everything. Please help me make this big!

in Research/Science 448 upvotes 3 years ago

Hair loss theory involves 3alpha-hydroxysteroid reductase (3AHD) converting DHT to androstenol. Discussion explores potential treatments and encourages more research.