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    Glossary Interleukin-18

    cytokine that promotes inflammation and immune responses

    Interleukin-18 (IL-18) is a cytokine, a type of protein that plays a crucial role in the immune system by promoting inflammation. It is involved in the body's defense mechanisms against infections and has been linked to various inflammatory and autoimmune conditions, including alopecia areata, where it can contribute to hair loss by triggering an immune response against hair follicles.

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    1. Association Between Interleukin 18 Polymorphisms and Alopecia Areata in Koreans Journal of Interferon & Cytokine Research · 2014 · 22 citations
    2. Genetic analysis of interleukin 18 gene polymorphisms in alopecia areata Journal of Clinical Laboratory Analysis · 2018 · 12 citations
    3. Serum Interleukin 18 and NLRP3 in patients with Alopecia Areata Benha Medical Journal · 2024
    4. Injury-induced interleukin-1 alpha promotes Lgr5 hair follicle stem cells de novo regeneration and proliferation via regulating regenerative microenvironment in mice Inflammation and Regeneration · 2023 · 7 citations
    5. Overexpression of IL-18 in the Proliferative Phase Endometrium of Patients With Polycystic Ovary Syndrome Reproductive Sciences · 2016 · 21 citations
    6. Erlotinib-Induced Skin Inflammation Is IL-1 Mediated in KC-Tie2 Mice and Human Skin Organ Culture 2014 · 15 citations
    7. Interleukin‐1 family cytokines and soluble receptors in hidradenitis suppurativa Experimental Dermatology · 2024 · 3 citations
    8. Interleukins gene polymorphism in alopecia areata patients: a systematic review 2025 · 1 citations
    9. Myrtus communis Leaf Extract Modulates IL-1α and VEGF Gene Expressions in HaCaT Cells: Probable Implications for Its Beneficial Effects in Hair Loss and Wound Healing Dove Medical Press (Taylor and Francis Group) · 2026
    10. Aberrant inflammasome activation as a driving force of human autoimmune skin disease Frontiers in immunology · 2023 · 3 citations
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