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GlossaryInterleukin-18

cytokine that promotes inflammation and immune responses

Interleukin-18 (IL-18) is a cytokine, a type of protein that plays a crucial role in the immune system by promoting inflammation. It is involved in the body's defense mechanisms against infections and has been linked to various inflammatory and autoimmune conditions, including alopecia areata, where it can contribute to hair loss by triggering an immune response against hair follicles.

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research Association Between Interleukin 18 Polymorphisms and Alopecia Areata in Koreans

22 citations, January 2014 in “Journal of Interferon & Cytokine Research”

Certain genetic variations in IL18 may increase the risk of alopecia areata in Koreans.

research Genetic Analysis of Interleukin 18 Gene Polymorphisms in Alopecia Areata

12 citations, January 2018 in “Journal of Clinical Laboratory Analysis”

Certain IL-18 gene variations may increase the risk of alopecia areata.

research Overexpression of IL-18 in the Proliferative Phase Endometrium of Patients With Polycystic Ovary Syndrome

21 citations, June 2016 in “Reproductive Sciences”

Women with PCOS, especially those overweight, have higher levels of IL-18 in their endometrium, which may affect fertility.

Preclinical Evidence Supporting Selective Inhibition of Tyrosine Kinase 2-Dependent, IL-12-Mediated Signaling as a Novel Strategy for Alopecia Areata Management

research Preclinical Evidence Supporting Selective Inhibition of Tyrosine Kinase 2-Dependent, IL-12-Mediated Signaling as a Novel Strategy for Alopecia Areata Management

November 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

Blocking TYK2 might be a new way to treat hair loss from alopecia areata.

Skin Organoids Derived From NCSTN Mutated Patient-Induced Pluripotent Stem Cells Recapitulate Hidradenitis Suppurativa Pathogenic Hallmarks

research Skin Organoids Derived From NCSTN Mutated Patient-Induced Pluripotent Stem Cells Recapitulate Hidradenitis Suppurativa Pathogenic Hallmarks

November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

Skin organoids with NCSTN mutation show changes in hair follicle development and higher inflammation, key features of Hidradenitis Suppurativa.

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community UPDATE: The theory that explains everything. Please help me make this big!

in Research/Science 449 upvotes 3 years ago

Hair loss theory involves 3alpha-hydroxysteroid reductase (3AHD) converting DHT to androstenol. Discussion explores potential treatments and encourages more research.

community NMN Promotes Cell Proliferation and Hair Growth by Reducing Oxidative Stress

in Research/Science 14 upvotes 5 months ago

NMN shows promise in promoting hair growth by reducing oxidative stress and weakening androgens. It may be a beneficial addition to hair loss treatments like Minoxidil and Finasteride.