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GlossaryInterleukin-13

protein that regulates inflammation and immune responses in the body

Interleukin-13 (IL-13) is a type of protein known as a cytokine, which plays a crucial role in the immune system by regulating inflammation and immune responses. It is particularly involved in allergic reactions and asthma, as it influences the behavior of various immune cells and can contribute to the development of conditions like atopic dermatitis and other inflammatory diseases.

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research Interleukin‐13 as a promising therapeutic target for alopecia areata associated with atopic dermatitis

January 2024 in “International Journal of Dermatology”

Targeting Interleukin-13 could help treat alopecia areata linked with atopic dermatitis.

1322 Molecular profiling of frontal fibrosing alopecia (FFA) reveals TH1 and JAK-STAT up-regulation with no suppression of hair keratins

research 1322 Molecular profiling of frontal fibrosing alopecia (FFA) reveals TH1 and JAK-STAT up-regulation with no suppression of hair keratins

2 citations , May 2018 in “Journal of Investigative Dermatology”

Frontal fibrosing alopecia shows increased inflammation and JAK-STAT pathway activity without reduced hair proteins.

$Dupilumab in the treatment of severe atopic dermatitis refractory to systemic immunosuppression: case report$

research Dupilumab in the treatment of severe atopic dermatitis refractory to systemic immunosuppression: case report

4 citations , January 2019 in “Einstein (São Paulo)”

Dupilumab improved severe atopic dermatitis in a patient who didn't respond to other treatments.

research The Role of Serum Th1, Th2, and Th17 Cytokines in Patients with Alopecia Areata: Clinical Implications

37 citations , December 2021 in “Cells”

Alopecia areata severity and treatment response are linked to specific cytokine levels.

research Toll-like Receptor 3 Agonist, Polyinosinic-polycytidylic Acid, Upregulates Carbonic Anhydrase II in Human Keratinocytes

9 citations , January 2018 in “Acta dermato-venereologica”

A substance called poly(I:C) increases a protein called carbonic anhydrase II in skin cells, which might help with skin defense and healing.

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community UPDATE: The theory that explains everything. Please help me make this big!

in Research/Science 448 upvotes 3 years ago

Hair loss theory involves 3alpha-hydroxysteroid reductase (3AHD) converting DHT to androstenol. Discussion explores potential treatments and encourages more research.