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    Glossary Interleukin-18

    cytokine that promotes inflammation and immune responses

    Interleukin-18 (IL-18) is a cytokine, a type of protein that plays a crucial role in the immune system by promoting inflammation. It is involved in the body's defense mechanisms against infections and has been linked to various inflammatory and autoimmune conditions, including alopecia areata, where it can contribute to hair loss by triggering an immune response against hair follicles.

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    1. Association Between Interleukin 18 Polymorphisms and Alopecia Areata in Koreans Journal of Interferon & Cytokine Research · 2014 · 22 citations
    2. Genetic analysis of interleukin 18 gene polymorphisms in alopecia areata Journal of Clinical Laboratory Analysis · 2018 · 12 citations
    3. Serum Interleukin 18 and NLRP3 in patients with Alopecia Areata Benha Medical Journal · 2024
    4. Injury-induced interleukin-1 alpha promotes Lgr5 hair follicle stem cells de novo regeneration and proliferation via regulating regenerative microenvironment in mice Inflammation and Regeneration · 2023 · 7 citations
    5. Overexpression of IL-18 in the Proliferative Phase Endometrium of Patients With Polycystic Ovary Syndrome Reproductive Sciences · 2016 · 21 citations
    6. Erlotinib-Induced Skin Inflammation Is IL-1 Mediated in KC-Tie2 Mice and Human Skin Organ Culture 2014 · 15 citations
    7. Interleukin‐1 family cytokines and soluble receptors in hidradenitis suppurativa Experimental Dermatology · 2024 · 3 citations
    8. Interleukins gene polymorphism in alopecia areata patients: a systematic review 2025 · 1 citations
    9. Myrtus communis Leaf Extract Modulates IL-1α and VEGF Gene Expressions in HaCaT Cells: Probable Implications for Its Beneficial Effects in Hair Loss and Wound Healing Dove Medical Press (Taylor and Francis Group) · 2026
    10. Aberrant inflammasome activation as a driving force of human autoimmune skin disease Frontiers in immunology · 2023 · 3 citations
    11. 27 Preclinical ex vivo and in vivo evidence supporting selective inhibition of tyrosine kinase 2-dependent, IL-12-mediated signaling as a novel pharmacological strategy for alopecia areata management 2023
    12. 545 Skin Organoids derived from NCSTN mutated patient-induced pluripotent stem cells recapitulate Hidradenitis Suppurativa pathogenic hallmarks 2022
    13. Tregs: Where We Are and What Comes Next? Frontiers in Immunology · 2017 · 130 citations
    14. 17β-estradiol Inhibits the Production of RANTES in Human Keratinocytes Journal of Investigative Dermatology · 2003 · 56 citations
    15. Enhanced cutaneous wound healing by functional injectable thermo-sensitive chitosan-based hydrogel encapsulated human umbilical cord-mesenchymal stem cells International Journal of Biological Macromolecules · 2019 · 48 citations
    16. The Effect of the Aqueous Extract of Bidens Pilosa L. on Androgen Deficiency Dry Eye in Rats Cellular Physiology and Biochemistry · 2016 · 27 citations
    17. Docosahexaenoic acid slows inflammation resolution and impairs the quality of healed skin tissue Clinical Science · 2019 · 8 citations
    18. Periplaneta americana extract (L.) promotes hair regrowth in Alopecia areata mice by reducing inflammation and modulating skin microbiota Frontiers in Pharmacology · 2025
    19. Rat Hair Follicle Stem Cell-Derived Exosomes: Isolation, Characterization and Comparative Analysis of Their In Vitro Wound Healing Potential International Journal of Molecular Sciences · 2025
    20. Cytostatics and immunosuppressive drugs Side effects of drugs annual · 1989
    21. Adverse cutaneous reactions to chemotherapeutic agents and cytokine therapy Seminars in Cutaneous Medicine and Surgery · 1996 · 18 citations
    22. <i>Trichophyton tonsurans</i>‐induced kerion celsi with decreased defensin expression and paradoxically increased interleukin‐17A production The Journal of Dermatology · 2019 · 7 citations
    23. Anagen hair follicles transplanted into mature human scars remodel fibrotic tissue npj regenerative medicine · 2023 · 6 citations
    24. Mechanisms of Puerariae Lobatae Radix in regulating sebaceous gland secretion: insights from network pharmacology and experimental validation Frontiers in Pharmacology · 2024 · 3 citations
    25. Screening of Anti-Hair Loss Plant Raw Materials Based on Reverse Network Pharmacology and Experimental Validation Current Issues in Molecular Biology · 2025
    26. Correlation of immunological variables of interleukin-17 and heat shock protein-70 in ethnic women with polycystic ovary syndrome South Eastern European Journal of Public Health · 2024
    27. Interleukin gene polymorphisms and alopecia areata: A systematic review and meta-analysis Medicine · 2024 · 2 citations
    28. Interleukin-25-Mediated-IL-17RB Upregulation Promotes Cutaneous Wound Healing in Diabetic Mice by Improving Endothelial Cell Functions Frontiers in Immunology · 2022 · 34 citations
    29. 061 Selective inhibition of tyrosine kinase 2 prevents and restores interleukin-12-induced hair follicle immune privilege collapse: a novel approach to alopecia areata therapy? Journal of Investigative Dermatology · 2021
    30. Effects of Topical application of Astragalus membranaceus in Spontaneous Alopecia Mice Model 2018 · 4 citations