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    Glossary Interleukin-12

    protein that activates immune cells to fight infections

    Interleukin-12 (IL-12) is a protein produced by certain immune cells that plays a crucial role in regulating the body's immune response. It helps activate natural killer (NK) cells and T cells, which are essential for fighting infections and cancer. IL-12 is also involved in the inflammatory response and can influence the development of autoimmune diseases.

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    1. 061 Selective inhibition of tyrosine kinase 2 prevents and restores interleukin-12-induced hair follicle immune privilege collapse: a novel approach to alopecia areata therapy? Journal of Investigative Dermatology · 2021
    2. A functional polymorphism in interleukin-1α (IL1A) gene is associated with risk of alopecia areata in Chinese populations Gene · 2013 · 11 citations
    3. Serum levels of interleukin-1 (IL-1α, IL-1β) in patients with alopecia areata Nasza Dermatologia Online · 2012 · 1 citations
    4. In Human Skin, UVB Initiates Early Induction of IL-10 Over IL-12 Preferentially in the Expanding Dermal Monocytic/Macrophagic Population Journal of Investigative Dermatology · 1998 · 101 citations
    5. 27 Preclinical ex vivo and in vivo evidence supporting selective inhibition of tyrosine kinase 2-dependent, IL-12-mediated signaling as a novel pharmacological strategy for alopecia areata management 2023
    6. Interleukins gene polymorphism in alopecia areata patients: a systematic review 2025 · 1 citations
    7. Dynamic interplay between IL-1 and WNT pathways in regulating dermal adipocyte lineage cells during skin development and wound regeneration Cell Reports · 2023 · 44 citations
    8. A ‘hot’ new twist to hair biology – involvement of vanilloid receptor‐1 signaling in human hair growth control Experimental Dermatology · 2004 · 2 citations
    9. Interleukin-1β Is Differentially Expressed by Human Dermal Papilla Cells in Response to PKC Activation and Is a Potent Inhibitor of Human Hair Follicle Growth in Organ Culture Journal of interferon & cytokine research · 1997 · 38 citations
    10. 128 Bimekizumab led to rapid & deep normalisation of molecular signatures associated with PASI sub-components, preceding clinical skin clearance Journal of Investigative Dermatology · 2024
    11. Interleukin-25-Mediated-IL-17RB Upregulation Promotes Cutaneous Wound Healing in Diabetic Mice by Improving Endothelial Cell Functions Frontiers in Immunology · 2022 · 34 citations
    12. Updated Treatment for Acne: Targeted Therapy Based on Pathogenesis Dermatology and Therapy · 2021 · 78 citations
    13. The Role of Serum Th1, Th2, and Th17 Cytokines in Patients with Alopecia Areata: Clinical Implications Cells · 2021 · 37 citations
    14. Pathogenetic Characteristics of Mesenchymal Stem Cells in Hidradenitis Suppurativa JAMA dermatology · 2018 · 19 citations
    15. Old Wine in New Bottles: Reviving Old Therapies for Alopecia Areata Using Rodent Models Journal of Investigative Dermatology Symposium Proceedings · 2003 · 17 citations
    16. Possible advantage of imiquimod and diphenylcyclopropenone combined treatment versus diphenylcyclopropenone alone: An observational study of nonresponder patients with alopecia areata Australasian journal of dermatology · 2016 · 9 citations
    17. Case Report: Successful Treatment of Alopecia Universalis With Tofacitinib and Increased Cytokine Levels: Normal Therapeutic Reaction or Danger Signal? Frontiers in Immunology · 2022
    18. Skin Care Properties of Grape Seed Polyphenols, a By-Product of the Winery Industry Humana Press eBooks · 2012
    19. Editors' Picks Journal of Investigative Dermatology · 2012
    20. Hypoxia enhances the hair growth-promoting effects of embryonic stem cell-derived mesenchymal stem cells via NADPH oxidase 4 Biomedicine & Pharmacotherapy · 2023
    21. Cutaneous scarring: Pathophysiology, molecular mechanisms, and scar reduction therapeutics Journal of the American Academy of Dermatology · 2011 · 232 citations
    22. Characterization of Hair Follicle Antigens Targeted by the Anti-Hair Follicle Immune Response Journal of Investigative Dermatology Symposium Proceedings · 2003 · 148 citations
    23. THE PATHOGENESIS OF ALOPECIA AREATA Dermatologic Clinics · 1996 · 89 citations
    24. Proinflammatory cytokines regulate epidermal stem cells in wound epithelialization Stem Cell Research & Therapy · 2020 · 65 citations
    25. Enhanced cutaneous wound healing by functional injectable thermo-sensitive chitosan-based hydrogel encapsulated human umbilical cord-mesenchymal stem cells International Journal of Biological Macromolecules · 2019 · 48 citations
    26. The Effect of the Aqueous Extract of Bidens Pilosa L. on Androgen Deficiency Dry Eye in Rats Cellular Physiology and Biochemistry · 2016 · 27 citations
    27. Effect of <i>Ficus carica</i> leaf extract on the gene expression of selected factors in HaCaT cells Journal of Cosmetic Dermatology · 2017 · 16 citations
    28. Transcriptome Meta-Analysis Confirms the Hidradenitis Suppurativa Pathogenic Triad: Upregulated Inflammation, Altered Epithelial Organization, and Dysregulated Metabolic Signaling Biomolecules · 2022 · 13 citations
    29. Altered expression of intracellular Toll-like receptors in peripheral blood mononuclear cells from patients with alopecia areata BBA clinical · 2016 · 12 citations
    30. Prevention of Alopecia in Medical and Interventional Chemotherapy Patients Journal of Cutaneous Medicine and Surgery · 2015 · 10 citations