Skin Care Properties of Grape Seed Polyphenols, a By-Product of the Winery Industry
October 2012
in “
Humana Press eBooks
”
grape seed polyphenols grape seed extract antioxidant anti-inflammatory antimicrobial anticarcinogenic hair follicle cell proliferation telogen phase anagen phase melasma skin carcinogenesis UVB-induced skin tumor inflammatory cytokines DNA repair mechanisms interleukin-12 hair growth hair cycle skin cancer UV protection inflammation DNA repair IL-12
TLDR Grape seed extract is good for skin care, with antioxidant, anti-inflammatory, and anti-cancer effects.
The document from 2012 reviews the beneficial skin care properties of grape seed polyphenols, by-products of the winery industry, highlighting their antioxidant, anti-inflammatory, antimicrobial, and anticarcinogenic effects. Studies cited include grape seed extract's promotion of hair follicle cell proliferation by 230% and conversion of hair cycles from telogen to anagen phase in mice, its potent antibacterial effects against MRSA, prevention of melasma in humans, and inhibition of skin carcinogenesis in mice. Grape seed extract also reduced UVB-induced skin tumor development, inflammation, and immunosuppression in mice by modulating inflammatory cytokines and enhancing DNA repair mechanisms, although these effects require interleukin-12. The extract was well-tolerated in rat toxicity studies, indicating safety for potential human studies. The document suggests the need for further research to understand grape seed polyphenols' pharmacological effects and to develop topical delivery systems.
