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GlossaryDNA repair

cell fixes damaged genetic material to prevent mutations

DNA repair is a collection of processes by which a cell identifies and corrects damage to its DNA molecules. This is crucial for maintaining the integrity of the genetic information, preventing mutations that could lead to diseases like cancer, and ensuring proper cellular function.

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research A Mouse Model for the Basal Transcription and DNA Repair Syndrome Trichothiodystrophy

188 citations, June 1998 in “Molecular cell”

Researchers created a mouse with the same mutation as humans with trichothiodystrophy, showing similar symptoms and confirming the condition is due to defects in DNA repair and gene activity.

research Melatonin as a Major Skin Protectant: From Free Radical Scavenging to DNA Damage Repair

160 citations, July 2008 in “Experimental dermatology”

Melatonin protects the skin by scavenging free radicals and repairing DNA damage.

research Comparison of DNA Repair Systems in Infant, Children, or Adult Skin Cells—Impact of Full-Solar-Spectrum Irradiation

August 2018 in “Journal of The American Academy of Dermatology”

Infant skin cells may be less capable of repairing UV-induced DNA damage than adult cells.

research Promotion of Homology-Directed DNA Repair by Polyamines

47 citations, January 2019 in “Nature communications”

Polyamines help fix DNA damage accurately in cells.

PBX1 Attenuates Hair Follicle-Derived Mesenchymal Stem Cell Senescence and Apoptosis by Alleviating Reactive Oxygen Species-Mediated DNA Damage Instead of Enhancing DNA Damage Repair

research PBX1 Attenuates Hair Follicle-Derived Mesenchymal Stem Cell Senescence and Apoptosis by Alleviating Reactive Oxygen Species-Mediated DNA Damage Instead of Enhancing DNA Damage Repair

9 citations, November 2021 in “Frontiers in Cell and Developmental Biology”

PBX1 helps reduce aging and cell death in hair follicle stem cells by decreasing DNA damage, not by improving DNA repair.

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community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

in Research/Science 732 upvotes 2 years ago

A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

community CRISPR Is Curing People Right Now. Genetic Hair Loss is Next?

in Technology 107 upvotes 1 month ago

CRISPR shows promise for treating hair loss by targeting specific genes. Current treatments include Minoxidil and finasteride, but CRISPR could offer a more precise solution, though it is still expensive and in early stages.

community The Real Cause Of Androgenetic Alopecia

in Research/Science 673 upvotes 1 month ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

community Why is dht bad for scalp hair but good for hair on the rest of body?

in Satire 109 upvotes 1 year ago

The conversation discusses why DHT (dihydrotestosterone) negatively affects scalp hair but promotes growth elsewhere on the body. Various opinions include genetic predispositions, differences in hair follicle reactions to DHT, and the potential role of Omega-3 in reducing inflammation and promoting hair health.

community Anyone excited for CosmeRNA coming this month?

in Product 171 upvotes 1 year ago

CosmeRNA, a new hair loss treatment, is expected to release soon and may become part of the "big three" treatments alongside finasteride and minoxidil. It works differently from finasteride by targeting androgen receptors in hair follicles, potentially offering fewer side effects.

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