Proliferation, DNA Repair, and Apoptosis in Androgenetic Alopecia

    January 2009 in “ Journal of The European Academy of Dermatology and Venereology ”
    Moetaz El-Domyati, Sonia Attia, Firas Saleh, MI Bassyouni, Hasan El-Fakahany, Hussein Abdel-Wahab
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    TLDR Bald areas have lower cell growth, more DNA damage, and increased cell death.
    This study investigated the role of cell proliferation, DNA repair, and apoptosis in androgenetic alopecia (AGA). The study found that the bald area of AGA had a lower proliferation rate and increased DNA damage, as evidenced by overexpression of XRCC1. The low levels of APE1 expression with concomitant overexpression of p53 would give the opportunity to an alternative pathway to take place in order to eliminate the damaged cells through apoptosis. The study highlights the role of proliferation, DNA damage, and apoptosis in the pathogenesis of AGA.
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