Proteomic Analysis of Balding and Non-Balding Mesenchyme-Derived Dermal Papilla Cells from Androgenetic Alopecia Patients Using Online Two-Dimensional Reversed Phase-Reversed Phase LC-MS/MS

June 2013 in “ Journal of Proteomics ”

Pyong-Gon Moon, Mi Hee Kwack, Jeong Min Lee, Young-Eun Cho, Jihwan Park, Daehee Hwang, Moon S. Kim, Jiyeon Kim, Young Chul Sung, Moon-Chang Baek

TLDR Found different proteins in balding and non-balding cells, giving insight into hair loss causes.

The study analyzed the protein expression of balding and non-balding dermal papilla cells from patients with androgenetic alopecia. The researchers identified differentially expressed proteins in balding DPCs compared to non-balding DPCs and confirmed some proteins belonging to the relevant pathways by Western blot and immunofluorescence analysis. The study provides insight into the pathogenesis of AGA and identifies potential biomarker candidates.

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