Proteomic Analysis of Balding and Non-Balding Mesenchyme-Derived Dermal Papilla Cells from Androgenetic Alopecia Patients Using Online Two-Dimensional Reversed Phase-Reversed Phase LC-MS/MS

April 2013 in “ Journal of Proteomics ”

Pyong-Gon Moon, Mi Hee Kwack, Jeong Min Lee, Young-Eun Cho, Jihwan Park, Daehee Hwang, Moon S. Kim, Jiyeon Kim, Young Chul Sung, Moon-Chang Baek

androgenetic alopecia dermal papilla cells protein expression Western blot immunofluorescence analysis pathogenesis biomarker candidates AGA DPCs

TLDR Found different proteins in balding and non-balding cells, giving insight into hair loss causes.

The study analyzed the protein expression of balding and non-balding dermal papilla cells from patients with androgenetic alopecia. The researchers identified differentially expressed proteins in balding DPCs compared to non-balding DPCs and confirmed some proteins belonging to the relevant pathways by Western blot and immunofluorescence analysis. The study provides insight into the pathogenesis of AGA and identifies potential biomarker candidates.

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Research cited in this study

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research Baldness And The Androgen Receptor: The AR Polyglycine Repeat Polymorphism Does Not Confer Susceptibility To Androgenetic Alopecia

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Hair loss in balding individuals is linked to changes in specific hair growth-related genes.

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277 citations, June 2003 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings”

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research Molecular Mechanisms Regulating Hair Follicle Development

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research Balding Hair Follicle Dermal Papilla Cells Contain Higher Levels of Androgen Receptors Than Those From Non-Balding Scalp

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